| http://purl.uniprot.org/citations/27864381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27864381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27864381 | http://www.w3.org/2000/01/rdf-schema#comment | "PUF family translational repressors are conserved developmental regulators, but the molecular function provided by the regions flanking the PUF RNA-binding domain is unknown. In C. elegans, the PUF proteins FBF-1 and FBF-2 support germline progenitor maintenance by repressing production of meiotic proteins and use distinct mechanisms to repress their target mRNAs. We identify dynein light chain DLC-1 as an important regulator of FBF-2 function. DLC-1 directly binds to FBF-2 outside of the RNA-binding domain and promotes FBF-2 localization and function. By contrast, DLC-1 does not interact with FBF-1 and does not contribute to FBF-1 activity. Surprisingly, we find that the contribution of DLC-1 to FBF-2 activity is independent of the dynein motor. Our findings suggest that PUF protein localization and activity are mediated by sequences flanking the RNA-binding domain that bind specific molecular partners. Furthermore, these results identify a new role for DLC-1 in post-transcriptional regulation of gene expression."xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.140921"xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.140921"xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/author | "Bailey J."xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/author | "Bailey J."xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/author | "Rasoloson D."xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/author | "Rasoloson D."xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/author | "Olson J.R."xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/author | "Olson J.R."xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/author | "Ellenbecker M."xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/author | "Ellenbecker M."xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/author | "Voronina E."xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/author | "Voronina E."xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/pages | "4643-4653"xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/pages | "4643-4653"xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/title | "Dynein light chain DLC-1 promotes localization and function of the PUF protein FBF-2 in germline progenitor cells."xsd:string |
| http://purl.uniprot.org/citations/27864381 | http://purl.uniprot.org/core/title | "Dynein light chain DLC-1 promotes localization and function of the PUF protein FBF-2 in germline progenitor cells."xsd:string |