| http://purl.uniprot.org/citations/27871366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27871366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27871366 | http://www.w3.org/2000/01/rdf-schema#comment | "The cytotoxicity of DNA-protein crosslinks (DPCs) is largely ascribed to their ability to block the progression of DNA replication. DPCs frequently occur in cells, either as a consequence of metabolism or exogenous agents, but the mechanism of DPC repair is not completely understood. Here, we characterize SPRTN as a specialized DNA-dependent and DNA replication-coupled metalloprotease for DPC repair. SPRTN cleaves various DNA binding substrates during S-phase progression and thus protects proliferative cells from DPC toxicity. Ruijs-Aalfs syndrome (RJALS) patient cells with monogenic and biallelic mutations in SPRTN are hypersensitive to DPC-inducing agents due to a defect in DNA replication fork progression and the inability to eliminate DPCs. We propose that SPRTN protease represents a specialized DNA replication-coupled DPC repair pathway essential for DNA replication progression and genome stability. Defective SPRTN-dependent clearance of DPCs is the molecular mechanism underlying RJALS, and DPCs are contributing to accelerated aging and cancer."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2016.09.032"xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2016.09.032"xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Fischer R."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Fischer R."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Gileadi O."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Gileadi O."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Amor D.J."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Amor D.J."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Lockhart P.J."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Lockhart P.J."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Kessler B.M."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Kessler B.M."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Freire R."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Freire R."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Newman J.A."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Newman J.A."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Halder S."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Halder S."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Popovic M."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Popovic M."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Ramadan K."xsd:string |
| http://purl.uniprot.org/citations/27871366 | http://purl.uniprot.org/core/author | "Ramadan K."xsd:string |