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http://purl.uniprot.org/citations/27871764http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27871764http://www.w3.org/2000/01/rdf-schema#comment"

Background and objective

Obesity is a factor that contributes to the morbidity of certain diseases and to worldwide mortality. MGAT1 is a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides and its polymorphisms are possibly involved in the etiology of obesity. We investigated the association of the rs4285184 polymorphism of the MGAT1 gene with obesity in adults in the State of Colima, Mexico.

Methods

A case-control study was conducted that included 244 subjects. All of them were grouped according to their percentage of body fat, determined through bioelectrical impedance, and they were genotyped for the rs4285184 polymorphism of the MGAT1 gene through PCR-RFLP. The results were analyzed for their association with the percentage of body fat.

Results

The G allele had a frequency of 49.19 and 38.75% for the cases and controls, respectively (P=.020) (OR 1.53; 95% CI 1.068-2.193). The frequency of the A/G+G/G genotype was 75% in the obese patients, which was significantly higher compared with the 57.5% of the control group (P=.004) (OR 2.217; 95% CI 1.287-3.821).

Conclusions

The presence of the rs4285184 polymorphism of the MGAT1 gene increased the risk for developing body fat associated with obesity in the Mexican population."xsd:string
http://purl.uniprot.org/citations/27871764http://purl.org/dc/terms/identifier"doi:10.1016/j.medcli.2016.07.037"xsd:string
http://purl.uniprot.org/citations/27871764http://purl.uniprot.org/core/author"Alvarez A."xsd:string
http://purl.uniprot.org/citations/27871764http://purl.uniprot.org/core/author"Valdez-Velazquez L.L."xsd:string
http://purl.uniprot.org/citations/27871764http://purl.uniprot.org/core/author"Delgado-Enciso I."xsd:string
http://purl.uniprot.org/citations/27871764http://purl.uniprot.org/core/author"Baltazar-Rodriguez L.M."xsd:string
http://purl.uniprot.org/citations/27871764http://purl.uniprot.org/core/author"Ramirez-Flores M."xsd:string
http://purl.uniprot.org/citations/27871764http://purl.uniprot.org/core/author"Cardenas-Rojas M.I."xsd:string
http://purl.uniprot.org/citations/27871764http://purl.uniprot.org/core/author"Guzman-Esquivel J."xsd:string
http://purl.uniprot.org/citations/27871764http://purl.uniprot.org/core/author"Bustos-Saldana R."xsd:string
http://purl.uniprot.org/citations/27871764http://purl.uniprot.org/core/author"Tapia-Rivera J.C."xsd:string
http://purl.uniprot.org/citations/27871764http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/27871764http://purl.uniprot.org/core/name"Med Clin (Barc)"xsd:string
http://purl.uniprot.org/citations/27871764http://purl.uniprot.org/core/pages"149-152"xsd:string
http://purl.uniprot.org/citations/27871764http://purl.uniprot.org/core/title"The rs4285184 polymorphism of the MGAT1 gene as a risk factor for obesity in the Mexican population."xsd:string
http://purl.uniprot.org/citations/27871764http://purl.uniprot.org/core/volume"148"xsd:string
http://purl.uniprot.org/citations/27871764http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27871764
http://purl.uniprot.org/citations/27871764http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/27871764
http://purl.uniprot.org/uniprot/#_B3KQW5-mappedCitation-27871764http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27871764
http://purl.uniprot.org/uniprot/#_B3KQ18-mappedCitation-27871764http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27871764
http://purl.uniprot.org/uniprot/#_P26572-mappedCitation-27871764http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27871764
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