| http://purl.uniprot.org/citations/27880902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27880902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27880902 | http://www.w3.org/2000/01/rdf-schema#comment | "Lymphocytes represent basic components of vertebrate adaptive immune systems, suggesting the utility of non-mammalian models to define the molecular basis of their development and differentiation. Our forward genetic screens in zebrafish for recessive mutations affecting early T cell development revealed several major genetic pathways. The identification of lineage-specific transcription factors and specific components of cytokine signaling and DNA replication and/or repair pathways known from studies of immunocompromised mammals provided an evolutionary cross-validation of the screen design. Unexpectedly, however, genes encoding proteins required for pre-mRNA processing were enriched in the collection of mutants identified here. In both zebrafish and mice, deficiency of the splice regulator TNPO3 impairs intrathymic T cell differentiation, illustrating the evolutionarily conserved and cell-type-specific functions of certain pre-mRNA-processing factors for T cell development."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.11.003"xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Boehm T."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Boehm T."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Schorpp M."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Schorpp M."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Hess I."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Hess I."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Monnich M."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Monnich M."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Iwanami N."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Iwanami N."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Sikora K."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Sikora K."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Guerri L."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Guerri L."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Lawir D.F."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Lawir D.F."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Mateos F."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Mateos F."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "O'Meara C.P."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "O'Meara C.P."xsd:string |
| http://purl.uniprot.org/citations/27880902 | http://purl.uniprot.org/core/author | "Richter A.S."xsd:string |