| http://purl.uniprot.org/citations/27880903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27880903 | http://www.w3.org/2000/01/rdf-schema#comment | "B cell development is a tightly regulated process dependent on sequential rearrangements of immunoglobulin loci that encode the antigen receptor. To elucidate the role of microRNAs (miRNAs) in the orchestration of B cell development, we ablated all miRNAs at the earliest stage of B cell development by conditionally targeting the enzymes critical for RNAi in early B cell precursors. Absence of any one of these enzymes led to a block at the pro-to pre-B cell transition due to increased apoptosis and a failure of pre-B cells to proliferate. Expression of a Bcl2 transgene allowed for partial rescue of B cell development, however, the majority of the rescued B cells had low surface immunoglobulin expression with evidence of ongoing light chain editing. Our analysis revealed that miRNAs are critical for the regulation of the PTEN-AKT-FOXO1 pathway that in turn controls Rag expression during B cell development."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.11.006"xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Chakraborty T."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Littman D.R."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Jensen K."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Skok J.A."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Melamed D."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Rajewsky K."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Blelloch R."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Silverman G.J."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Benhamou D."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Koralov S.B."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Coffre M."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Bajwa S."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Riess D."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Blumenberg L."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Calado D."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Chong M.M.W."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Getu L."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Hines M.J."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/author | "Snetkova V."xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/27880903 | http://purl.uniprot.org/core/pages | "2271-2285"xsd:string |