| http://purl.uniprot.org/citations/27882436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27882436 | http://www.w3.org/2000/01/rdf-schema#comment | "Condensed-bicyclic 4,6-substituted1,2,4-triazolo-1,3,4-thiadiazole derivatives (CBTT) have been shown to possess a wide spectrum of pharmacological activities. In this study, several novel CBTT derivatives were synthesized and investigated for their possible role as anti-neoplastic agents. The anti-proliferative effect of various CBTT derivatives was analyzed against tumor cell lines by (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT assay. One of the potential CBTT derivative, 5-(3-(2,3-dichlorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)flurobenzonitrile (DTTF) was found to be the most potent against cervical cancer SiHa cells and exhibited minimal effect against normal cells. Molecular docking analysis indicated that transcription factor NF-κB was one of the potential molecular targets modulated by DTTF. Specifically, the drug blocked the TNFα-induced phosphorylation of upstream IκBα kinase in a time-dependent manner leading to the suppression of NF-κB activation and nuclear translocation. DTTF also potentiated the apoptotic effect of TNFα, as well as significantly inhibited migration and invasion of tumor cells. Overall, these findings indicate a potential novel role and mechanism(s) of action of DTTF as an anticancer agent against diverse malignancies."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10495-016-1312-8"xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/author | "Bist P."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/author | "Rangappa K.S."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/author | "Rajendran P."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/author | "Sethi G."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/author | "Shanmugam M.K."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/author | "Alharbi S.A."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/author | "Basappa"xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/author | "Chinnathambi A."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/author | "Achar R.R."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/author | "Lim L.H.K."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/author | "Ningegowda R."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/author | "Priya B.S."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/author | "Shivananju N.S."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/name | "Apoptosis"xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/pages | "145-157"xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/title | "A novel 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivative inhibits tumor cell invasion and potentiates the apoptotic effect of TNFalpha by abrogating NF-kappaB activation cascade."xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/27882436 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27882436 |
| http://purl.uniprot.org/citations/27882436 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27882436 |
| http://purl.uniprot.org/uniprot/#_A0A0G2YPN5-mappedCitation-27882436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27882436 |