| http://purl.uniprot.org/citations/27882935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27882935 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular permeability and neovascularization are implicated in many diseases including retinopathies and diabetic wound healing. Robo4 is an endothelial-specific transmembrane receptor that stabilizes the vasculature, as shown in Robo4-/- mice that develop hyperpermeability, but how Robo4 signals remained unclear. Here we show that Robo4 deletion enhances permeability and revascularization in oxygen-induced retinopathy (OIR) and accelerates cutaneous wound healing. To determine Robo4 signalling pathways, we generated transgenic mice expressing a truncated Robo4 lacking the cytoplasmic domain (Robo4ΔCD). Robo4ΔCD expression is sufficient to prevent permeability, and inhibits OIR revascularization and wound healing in Robo4-/- mice. Mechanistically, Robo4 does not affect Slit2 signalling, but Robo4 and Robo4ΔCD counteract Vegfr2-Y949 (Y951 in human VEGFR2) phosphorylation by signalling through the endothelial UNC5B receptor. We conclude that Robo4 inhibits angiogenesis and vessel permeability independently of its cytoplasmic domain, while activating VEGFR2-Y951 via ROBO4 inhibition might accelerate tissue revascularization in retinopathy of prematurity and in diabetic patients."xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms13517"xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://purl.uniprot.org/core/author | "Eichmann A."xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://purl.uniprot.org/core/author | "Dubrac A."xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://purl.uniprot.org/core/author | "Tong R."xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://purl.uniprot.org/core/author | "Mathivet T."xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://purl.uniprot.org/core/author | "Prahst C."xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://purl.uniprot.org/core/author | "Pibouin-Fragner L."xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://purl.uniprot.org/core/author | "Genet G."xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27882935 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://purl.uniprot.org/core/pages | "13517"xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://purl.uniprot.org/core/title | "The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization."xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27882935 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27882935 |
| http://purl.uniprot.org/citations/27882935 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27882935 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J197-mappedCitation-27882935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27882935 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SSV2-mappedCitation-27882935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27882935 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SUF8-mappedCitation-27882935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27882935 |
| http://purl.uniprot.org/uniprot/#_D3Z4M4-mappedCitation-27882935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27882935 |
| http://purl.uniprot.org/uniprot/#_P35968-mappedCitation-27882935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27882935 |
| http://purl.uniprot.org/uniprot/#_Q6IR38-mappedCitation-27882935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27882935 |