| http://purl.uniprot.org/citations/27897269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27897269 | http://www.w3.org/2000/01/rdf-schema#comment | "Edoxaban and its low-abundance, active metabolite M4 are substrates of P-glycoprotein (P-gp; MDR1) and organic anion transporter protein 1B1 (OATP1B1), respectively, and pharmacological inhibitors of P-gp and OATP1B1 can affect edoxaban and M4 pharmacokinetics (PK). In this integrated pharmacogenomic analysis, genotype and concentration-time data from 458 healthy volunteers in 14 completed phase 1 studies were pooled to examine the impact on edoxaban PK parameters of allelic variants of ABCB1 (rs1045642: C3435T) and SLCO1B1 (rs4149056: T521C), which encode for P-gp and OATP1B1. Although some pharmacologic inhibitors of P-gp and OATP1B1 increase edoxaban exposure, neither the ABCB1 C3435T nor the SLCO1B1 T521C polymorphism affected edoxaban PK. A slight elevation in M4 exposure was observed among SLCO1B1 C-allele carriers; however, this elevation is unlikely to be clinically significant as plasma M4 concentrations comprise <10% of total edoxaban levels."xsd:string |
| http://purl.uniprot.org/citations/27897269 | http://purl.org/dc/terms/identifier | "doi:10.1038/tpj.2016.82"xsd:string |
| http://purl.uniprot.org/citations/27897269 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/27897269 | http://purl.uniprot.org/core/author | "Shi M."xsd:string |
| http://purl.uniprot.org/citations/27897269 | http://purl.uniprot.org/core/author | "Walker J.R."xsd:string |
| http://purl.uniprot.org/citations/27897269 | http://purl.uniprot.org/core/author | "Brown K.S."xsd:string |
| http://purl.uniprot.org/citations/27897269 | http://purl.uniprot.org/core/author | "Vandell A.G."xsd:string |
| http://purl.uniprot.org/citations/27897269 | http://purl.uniprot.org/core/author | "Rubets I."xsd:string |
| http://purl.uniprot.org/citations/27897269 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/27897269 | http://purl.uniprot.org/core/name | "Pharmacogenomics J"xsd:string |
| http://purl.uniprot.org/citations/27897269 | http://purl.uniprot.org/core/pages | "153-159"xsd:string |
| http://purl.uniprot.org/citations/27897269 | http://purl.uniprot.org/core/title | "An integrated pharmacokinetic/pharmacogenomic analysis of ABCB1 and SLCO1B1 polymorphisms on edoxaban exposure."xsd:string |
| http://purl.uniprot.org/citations/27897269 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/27897269 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27897269 |
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