| http://purl.uniprot.org/citations/27901020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27901020 | http://www.w3.org/2000/01/rdf-schema#comment | "Netrins, a family of laminin-related molecules, have been proposed to act as guidance cues either during nervous system development or the establishment of the vascular system. This was clearly demonstrated for netrin-1 via its interaction with the receptors DCC and UNC5s. However, mainly based on shared homologies with netrin-1, netrin-4 was also proposed to play a role in neuronal outgrowth and developmental/pathological angiogenesis via interactions with netrin-1 receptors. Here, we present the high-resolution structure of netrin-4, which shows unique features in comparison with netrin-1, and show that it does not bind directly to any of the known netrin-1 receptors. We show that netrin-4 disrupts laminin networks and basement membranes (BMs) through high-affinity binding to the laminin γ1 chain. We hypothesize that this laminin-related function is essential for the previously described effects on axon growth promotion and angiogenesis. Our study unveils netrin-4 as a non-enzymatic extracellular matrix protein actively disrupting pre-existing BMs."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms13515"xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Meier M."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Metzger S."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Stetefeld J."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Bald T."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Patel T.R."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Yurchenco P.D."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Koch M."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "McDougall M."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Mehlen P."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Zigrino P."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Bloch W."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Djonov V."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "McKee K.K."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Rama N."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Poschl E."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Nikodemus D."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Delcros J.G."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Ehrbar M."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Tuting T."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Gibert B."xsd:string |
| http://purl.uniprot.org/citations/27901020 | http://purl.uniprot.org/core/author | "Kaltenberg J."xsd:string |