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http://purl.uniprot.org/citations/27908841http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objective

Oxidative stress plays an important role in the pathogenesis of type 1 diabetes mellitus (T1DM). To evaluate the association of glutathione S-transferase mu 1 (GST M1) and glutathione S-transferase theta 1 (GST T1) polymorphisms with development of T1DM and disease-related risk factors.

Methods

Measurement of fasting glucose, serum creatinine, lipid profile, and glycosylated hemoglobin (HbA1c), as well as evaluation of GST T1 and M1 genetic polymorphisms using polymerase chain reaction were done in 64 diabetic children and 41 controls.

Results

The diabetic group had significantly higher fasting glucose, HbA1c, and cholesterol levels. GST T1 null genotype was more frequent in the diabetic than the control group with 4.2-fold increased risk of T1DM (odds ratio=4.2; 95% confidence interval=1.6-11.5; p=0.03). Significant positive associations were found with lipid profile, HbA1c, and duration of illness but not with age, age at onset, and body mass index.

Conclusion

Gene polymorphisms of the enzyme GST are associated with development of T1DM and disease-related risk factors."xsd:string
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http://purl.uniprot.org/citations/27908841http://purl.uniprot.org/core/author"Barseem N."xsd:string
http://purl.uniprot.org/citations/27908841http://purl.uniprot.org/core/author"Elsamalehy M."xsd:string
http://purl.uniprot.org/citations/27908841http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/27908841http://purl.uniprot.org/core/name"J Clin Res Pediatr Endocrinol"xsd:string
http://purl.uniprot.org/citations/27908841http://purl.uniprot.org/core/pages"138-143"xsd:string
http://purl.uniprot.org/citations/27908841http://purl.uniprot.org/core/title"Gene Polymorphisms of Glutathione S-Transferase T1/M1 in Egyptian Children and Adolescents with Type 1 Diabetes Mellitus."xsd:string
http://purl.uniprot.org/citations/27908841http://purl.uniprot.org/core/volume"9"xsd:string
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