| http://purl.uniprot.org/citations/27915416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27915416 | http://www.w3.org/2000/01/rdf-schema#comment | "G1 phase cell cycle proteins, such as cyclin-dependent kinase 6 (Cdk6) and its activating partners, the D-type cyclins, are important regulators of T-cell development and function. An F-box protein, called F-box only protein 7 (Fbxo7), acts as a cell cycle regulator by enhancing cyclin D-Cdk6 complex formation and stabilising levels of p27, a cyclin-dependent kinase inhibitor. We generated a murine model of reduced Fbxo7 expression to test its physiological role in multiple tissues and found that these mice displayed a pronounced thymic hypoplasia. Further analysis revealed that Fbxo7 differentially affected proliferation and apoptosis of thymocytes at various stages of differentiation in the thymus and also mature T-cell function and proliferation in the periphery. Paradoxically, Fbxo7-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. Our studies reveal differential cell cycle regulation by Fbxo7 at different stages in T-cell development."xsd:string |
| http://purl.uniprot.org/citations/27915416 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-016-2427-3"xsd:string |
| http://purl.uniprot.org/citations/27915416 | http://purl.uniprot.org/core/author | "Laman H."xsd:string |
| http://purl.uniprot.org/citations/27915416 | http://purl.uniprot.org/core/author | "Cooke A."xsd:string |
| http://purl.uniprot.org/citations/27915416 | http://purl.uniprot.org/core/author | "Gibbs S."xsd:string |
| http://purl.uniprot.org/citations/27915416 | http://purl.uniprot.org/core/author | "Randle S.J."xsd:string |
| http://purl.uniprot.org/citations/27915416 | http://purl.uniprot.org/core/author | "Patel S.P."xsd:string |
| http://purl.uniprot.org/citations/27915416 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27915416 | http://purl.uniprot.org/core/name | "Cell Mol Life Sci"xsd:string |
| http://purl.uniprot.org/citations/27915416 | http://purl.uniprot.org/core/pages | "1553-1566"xsd:string |
| http://purl.uniprot.org/citations/27915416 | http://purl.uniprot.org/core/title | "Opposing effects on the cell cycle of T lymphocytes by Fbxo7 via Cdk6 and p27."xsd:string |
| http://purl.uniprot.org/citations/27915416 | http://purl.uniprot.org/core/volume | "74"xsd:string |
| http://purl.uniprot.org/citations/27915416 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27915416 |
| http://purl.uniprot.org/citations/27915416 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27915416 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2JGH2-mappedCitation-27915416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27915416 |
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| http://purl.uniprot.org/uniprot/#_Q0VBK8-mappedCitation-27915416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27915416 |
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| http://purl.uniprot.org/uniprot/#_Q64261-mappedCitation-27915416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27915416 |
| http://purl.uniprot.org/uniprot/#_Q3UGI9-mappedCitation-27915416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27915416 |
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| http://purl.uniprot.org/uniprot/#_Q4FJM2-mappedCitation-27915416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27915416 |