| http://purl.uniprot.org/citations/27916085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27916085 | http://www.w3.org/2000/01/rdf-schema#comment | "Objective To investigate the effect of siRNA-mediated chemokine receptor 7 (CCR7) silence on the proliferation, migration, invasion and apoptosis of human MG-63 osteosarcoma cells. Methods The study designed and synthesized siRNA targeting CCR7 (CCR7-siRNA). After MG63 cells were transfected with CCR7-siRNA, the expression of CCR7 was identified by Western blotting; cell apoptosis was detected by annexinV-FITC/PI double staining combined with flow cemetery; cell proliferation was tested by MTT assay; and cell migration and invasion abilities were examined by TranswellTM migration/invasion assays. Results CCR7 expression in MG63 cells was significantly inhibited after transfected with CCR7-siRNA. At the same time, cell proliferation, migration and invasion abilities were distinctly suppressed, and cell apoptosis rate increased. Conclusion Down-regulating CCR7 expression in MG63 cells could apparently inhibit cell proliferation, migration and invasion abilities of MG63 cells, and also induce cell apoptosis."xsd:string |
| http://purl.uniprot.org/citations/27916085 | http://purl.uniprot.org/core/author | "Ma B."xsd:string |
| http://purl.uniprot.org/citations/27916085 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/27916085 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/27916085 | http://purl.uniprot.org/core/author | "Ma Q."xsd:string |
| http://purl.uniprot.org/citations/27916085 | http://purl.uniprot.org/core/author | "Yan S."xsd:string |
| http://purl.uniprot.org/citations/27916085 | http://purl.uniprot.org/core/author | "Zhang E."xsd:string |
| http://purl.uniprot.org/citations/27916085 | http://purl.uniprot.org/core/author | "E Z."xsd:string |
| http://purl.uniprot.org/citations/27916085 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27916085 | http://purl.uniprot.org/core/name | "Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"xsd:string |
| http://purl.uniprot.org/citations/27916085 | http://purl.uniprot.org/core/pages | "1585-1589"xsd:string |
| http://purl.uniprot.org/citations/27916085 | http://purl.uniprot.org/core/title | "[CCR7 silence by siRNA inhibits proliferation, invasion and promotes apoptosis of human MG63 osteosarcoma cells]."xsd:string |
| http://purl.uniprot.org/citations/27916085 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/27916085 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27916085 |
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