| http://purl.uniprot.org/citations/27923704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27923704 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling through the IL-17 receptor (IL-17R) is required to prevent oropharyngeal candidiasis (OPC) in mice and humans. However, the IL-17-responsive cell type(s) that mediate protection are unknown. Using radiation chimeras, we were able to rule out a requirement for IL-17RA in the hematopoietic compartment. We saw remarkable concordance of IL-17-controlled gene expression in C. albicans-infected human oral epithelial cells (OECs) and in tongue tissue from mice with OPC. To interrogate the role of the IL-17R in OECs, we generated mice with conditional deletion of IL-17RA in superficial oral and esophageal epithelial cells (Il17raΔK13). Following oral Candida infection, Il17raΔK13 mice exhibited fungal loads and weight loss indistinguishable from Il17ra-/- mice. Susceptibility in Il17raΔK13 mice correlated with expression of the antimicrobial peptide β-defensin 3 (BD3, Defb3). Consistently, Defb3-/- mice were susceptible to OPC. Thus, OECs dominantly control IL-17R-dependent responses to OPC through regulation of BD3 expression."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2016.10.001"xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Daugherty S."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Sinha S."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Richardson J.P."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Bruno V.M."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Solis N."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Filler S.G."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Kolls J.K."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Naglik J.R."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Conti H.R."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Coleman B.M."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Gaffen S.L."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Verma A.H."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Cruz J.A."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Hise A.G."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Childs E.E."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Garg A.V."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Brane L."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Hendricks M.R."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Hunter J.P."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Mengesha B.G."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/author | "Saevig D.L."xsd:string |
| http://purl.uniprot.org/citations/27923704 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |