| http://purl.uniprot.org/citations/27926863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27926863 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic infections affect a third of the world's population and can cause bone marrow suppression, a severe condition that increases mortality from infection. To uncover the basis for infection-associated bone marrow suppression, we conducted repeated infection of WT mice with Mycobacterium avium. After 4-6 months, mice became pancytopenic. Their hematopoietic stem and progenitor cells (HSPCs) were severely depleted and displayed interferon gamma (IFN-γ) signaling-dependent defects in self-renewal. There was no evidence of increased HSPC mobilization or apoptosis. However, consistent with known effects of IFN-γ, transcriptome analysis pointed toward increased myeloid differentiation of HSPCs and revealed the transcription factor Batf2 as a potential mediator of IFN-γ-induced HSPC differentiation. Gain- and loss-of-function studies uncovered a role for Batf2 in myeloid differentiation in both murine and human systems. We thus demonstrate that chronic infection can deplete HSPCs and identify BATF2 as a mediator of infection-induced HSPC terminal differentiation."xsd:string |
| http://purl.uniprot.org/citations/27926863 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.11.031"xsd:string |
| http://purl.uniprot.org/citations/27926863 | http://purl.uniprot.org/core/author | "Chen F."xsd:string |
| http://purl.uniprot.org/citations/27926863 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/27926863 | http://purl.uniprot.org/core/author | "Sun D."xsd:string |
| http://purl.uniprot.org/citations/27926863 | http://purl.uniprot.org/core/author | "Jeong M."xsd:string |
| http://purl.uniprot.org/citations/27926863 | http://purl.uniprot.org/core/author | "Mo Q."xsd:string |
| http://purl.uniprot.org/citations/27926863 | http://purl.uniprot.org/core/author | "King K.Y."xsd:string |
| http://purl.uniprot.org/citations/27926863 | http://purl.uniprot.org/core/author | "Matatall K.A."xsd:string |
| http://purl.uniprot.org/citations/27926863 | http://purl.uniprot.org/core/author | "Kimmel M."xsd:string |
| http://purl.uniprot.org/citations/27926863 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27926863 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/27926863 | http://purl.uniprot.org/core/pages | "2584-2595"xsd:string |
| http://purl.uniprot.org/citations/27926863 | http://purl.uniprot.org/core/title | "Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation."xsd:string |
| http://purl.uniprot.org/citations/27926863 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/27926863 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27926863 |
| http://purl.uniprot.org/citations/27926863 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27926863 |
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| http://purl.uniprot.org/uniprot/#_B4DV37-mappedCitation-27926863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27926863 |
| http://purl.uniprot.org/uniprot/#_E9PX11-mappedCitation-27926863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27926863 |
| http://purl.uniprot.org/uniprot/#_Q540M5-mappedCitation-27926863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27926863 |
| http://purl.uniprot.org/uniprot/#_Q3U8T2-mappedCitation-27926863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27926863 |
| http://purl.uniprot.org/uniprot/#_Q3TW49-mappedCitation-27926863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27926863 |
| http://purl.uniprot.org/uniprot/#_Q8R1H8-mappedCitation-27926863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27926863 |