| http://purl.uniprot.org/citations/27926878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27926878 | http://www.w3.org/2000/01/rdf-schema#comment | "The transmembrane adaptor PAG (Cbp) has been proposed to mediate membrane recruitment of Csk, a cytoplasmic protein tyrosine kinase playing a critical inhibitory role during T cell activation, by inactivating membrane-associated Src kinases. However, this model has not been validated by genetic evidence. Here, we demonstrate that PAG-deficient mice display enhanced T cell activation responses in effector, but not in naive, T cells. PAG-deficient mice also have augmented T cell-dependent autoimmunity and greater resistance to T cell anergy. Interestingly, in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells. Thus, Csk-associating PAG is a critical component of the inhibitory machinery controlling effector T cell activation in cooperation with PTPN22 and Dok adaptors."xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.11.035"xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://purl.uniprot.org/core/author | "Gu H."xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://purl.uniprot.org/core/author | "Xavier R.J."xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://purl.uniprot.org/core/author | "Seed B."xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://purl.uniprot.org/core/author | "Pandolfi P.P."xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://purl.uniprot.org/core/author | "Davidson D."xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://purl.uniprot.org/core/author | "Veillette A."xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://purl.uniprot.org/core/author | "Zhong M.C."xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://purl.uniprot.org/core/author | "Bolland S."xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27926878 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://purl.uniprot.org/core/pages | "2776-2788"xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://purl.uniprot.org/core/title | "The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors."xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/27926878 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27926878 |
| http://purl.uniprot.org/citations/27926878 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27926878 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP17-mappedCitation-27926878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27926878 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP47-mappedCitation-27926878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27926878 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP95-mappedCitation-27926878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27926878 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STA1-mappedCitation-27926878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27926878 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW01-mappedCitation-27926878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27926878 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW29-mappedCitation-27926878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27926878 |