| http://purl.uniprot.org/citations/27927647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27927647 | http://www.w3.org/2000/01/rdf-schema#comment | "Allogeneic bone marrow transplantation (allo-BMT) is a curative therapy for hematological malignancies, but is associated with significant complications, principally graft-versus-host disease (GVHD) and opportunistic infections. Natural killer (NK) cells mediate important innate immunity that provides a temporal bridge until the reconstruction of adaptive immunity. Here, we show that the development of GVHD after allo-BMT prevented NK-cell reconstitution, particularly within the maturing M1 and M2 NK-cell subsets in association with exaggerated activation, apoptosis, and autophagy. Donor T cells were critical in this process by limiting the availability of interleukin 15 (IL-15), and administration of IL-15/IL-15Rα or immune suppression with rapamycin could restore NK-cell reconstitution. Importantly, the NK-cell defect induced by GVHD resulted in the failure of NK-cell-dependent in vivo cytotoxicity and graft-versus-leukemia effects. Control of cytomegalovirus infection after allo-BMT was also impaired during GVHD. Thus, during GVHD, donor T cells compete with NK cells for IL-15 thereby inducing profound defects in NK-cell reconstitution that compromise both leukemia and pathogen-specific immunity."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2016-08-734020"xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Lane S.W."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Bunting M.D."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Smyth M.J."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Blazar B.R."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Degli-Esposti M.A."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Hill G.R."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Tey S.K."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Huntington N.D."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Lineburg K.E."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Fleming P."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "MacDonald K.P."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Varelias A."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Kuns R.D."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Souza-Fonseca-Guimaraes F."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Schuster I.S."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/author | "Locke K.R."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/pages | "630-642"xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/title | "GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity."xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/27927647 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27927647 |