| http://purl.uniprot.org/citations/27929607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27929607 | http://www.w3.org/2000/01/rdf-schema#comment | "The Rab-GTPase-activating proteins (GAPs) TBC1D1 and TBC1D4 play important roles in the insulin-stimulated translocation of the glucose transporter GLUT4 from intracellular vesicles to the plasma membrane in muscle cells and adipocytes. We identified Rab28 as a substrate for the GAP domains of both TBC1D1 and TBC1D4 in vitro. Rab28 is expressed in adipose cells and skeletal muscle, and its GTP-binding state is acutely regulated by insulin. We found that in intact isolated mouse skeletal muscle, siRNA-mediated knockdown of Rab28 decreases basal glucose uptake. Conversely, in primary rat adipose cells, overexpression of Rab28-Q72L, a constitutively active mutant, increases basal cell surface levels of an epitope-tagged HA-GLUT4. Our results indicate that Rab28 is a novel GTPase involved in the intracellular retention of GLUT4 in insulin target cells."xsd:string |
| http://purl.uniprot.org/citations/27929607 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.12509"xsd:string |
| http://purl.uniprot.org/citations/27929607 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/27929607 | http://purl.uniprot.org/core/author | "Holman G.D."xsd:string |
| http://purl.uniprot.org/citations/27929607 | http://purl.uniprot.org/core/author | "Al-Hasani H."xsd:string |
| http://purl.uniprot.org/citations/27929607 | http://purl.uniprot.org/core/author | "Du C."xsd:string |
| http://purl.uniprot.org/citations/27929607 | http://purl.uniprot.org/core/author | "Menzel F."xsd:string |
| http://purl.uniprot.org/citations/27929607 | http://purl.uniprot.org/core/author | "Chadt A."xsd:string |
| http://purl.uniprot.org/citations/27929607 | http://purl.uniprot.org/core/author | "Benninghoff T."xsd:string |
| http://purl.uniprot.org/citations/27929607 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27929607 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/27929607 | http://purl.uniprot.org/core/pages | "88-96"xsd:string |
| http://purl.uniprot.org/citations/27929607 | http://purl.uniprot.org/core/title | "Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking."xsd:string |
| http://purl.uniprot.org/citations/27929607 | http://purl.uniprot.org/core/volume | "591"xsd:string |
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