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http://purl.uniprot.org/citations/27930522http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27930522http://www.w3.org/2000/01/rdf-schema#comment"

Background

Promoter hypermethylation of Wnt inhibitory factor-1 (WIF-1)-a tumor suppressor gene-has been detected in several types of human tumors. However, the association between WIF-1 promoter hypermethylation and lung cancer remains to be elucidated. Therefore, we conducted this study to evaluate the clinical significance of WIF-1 promoter hypermethylation in lung cancer.

Methods

A comprehensive literature search was conducted to obtain eligible studies. The combined odds ratios (ORs) or hazard ratios and 95% confidence intervals were used to estimate the strength of associations.

Results

A total of 8 eligible publications with 626 cases and 512 controls were included in our study. The combined ORs revealed that WIF-1 promoter hypermethylation was significantly higher in lung cancer than in controls (OR 10.53, P < 0.001). Moreover, WIF-1 promoter hypermethylation was significantly associated with smoking behavior (OR 1.88, P = 0.002). No significant correlation was found between WIF-1 promoter hypermethylation and sex status, age status, tumor stage, and pathological types in cancer. Multivariate analysis results indicated the absence of correlation between WIF-1 promoter hypermethylation and with relapse-free survival and overall survival. Subgroup analysis by sample type demonstrated that promoter hypermethylation of WIF-1 was significantly associated with an increased risk of lung cancer in the tissue (OR 7.89, P < 0.001), blood (OR 21.83, P = 0.034), and pleural effusion subgroups (OR 157.43, P = 0.001).

Conclusions

Promoter hypermethylation of WIF-1 may play a crucial role in lung cancer carcinogenesis. It may be a noninvasive biomarker using blood or pleural effusion detection. WIF-1 promoter hypermethylation is correlated with smoking behavior, but not with sex status, age status, tumor stage, pathological types, and the prognosis of lung cancer patients in terms of relapse-free survival and overall survival. More investigations, including a larger number of subjects, are required to further confirm the findings of our analysis."xsd:string
http://purl.uniprot.org/citations/27930522http://purl.org/dc/terms/identifier"doi:10.1097/md.0000000000005433"xsd:string
http://purl.uniprot.org/citations/27930522http://purl.uniprot.org/core/author"Jiang Y."xsd:string
http://purl.uniprot.org/citations/27930522http://purl.uniprot.org/core/author"Liang X."xsd:string
http://purl.uniprot.org/citations/27930522http://purl.uniprot.org/core/author"Li X."xsd:string
http://purl.uniprot.org/citations/27930522http://purl.uniprot.org/core/author"Song B."xsd:string
http://purl.uniprot.org/citations/27930522http://purl.uniprot.org/core/author"Yang X."xsd:string
http://purl.uniprot.org/citations/27930522http://purl.uniprot.org/core/author"Zheng Y."xsd:string
http://purl.uniprot.org/citations/27930522http://purl.uniprot.org/core/author"Xu Y."xsd:string
http://purl.uniprot.org/citations/27930522http://purl.uniprot.org/core/author"Zhou Q."xsd:string
http://purl.uniprot.org/citations/27930522http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27930522http://purl.uniprot.org/core/name"Medicine (Baltimore)"xsd:string
http://purl.uniprot.org/citations/27930522http://purl.uniprot.org/core/pages"e5433"xsd:string
http://purl.uniprot.org/citations/27930522http://purl.uniprot.org/core/title"Promoter hypermethylation of Wnt inhibitory factor-1 in patients with lung cancer: A systematic meta-analysis."xsd:string
http://purl.uniprot.org/citations/27930522http://purl.uniprot.org/core/volume"95"xsd:string
http://purl.uniprot.org/citations/27930522http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27930522
http://purl.uniprot.org/citations/27930522http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/27930522
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