| http://purl.uniprot.org/citations/27932517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27932517 | http://www.w3.org/2000/01/rdf-schema#comment | "TLR2 recognizes cell wall components of Staphylococcus aureus, which colonizes >90% of atopic eczematous skin lesions. The regulatory mechanisms of TLR2 signaling in the skin remain unclear. Allergin-1, an inhibitory immunoglobulin-like receptor containing an ITIM, is expressed on mast cells (MCs) and inhibits IgE-mediated anaphylaxis in mice. Here, we show that Allergin-1 inhibits TLR2-mediated activation of, and inflammatory cytokine production by, MCs in vitro Compared with wild-type mice, Allergin-1-deficient mice showed enhanced ear swelling with enhanced collagen deposition and greater Ly6G+ neutrophil recruitment after intra-dermal injection of Pam2CSK4 into pinnae. Using Mas-TRECK mice, which is an MC deletion system based on il4 enhancer elements, we also demonstrated that Allergin-1 on MCs is responsible for the Pam2CSK4-induced ear swelling. These results suggest that Allergin-1 on skin MCs suppresses TLR2-induced dermatitis."xsd:string |
| http://purl.uniprot.org/citations/27932517 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxw046"xsd:string |
| http://purl.uniprot.org/citations/27932517 | http://purl.uniprot.org/core/author | "Imai M."xsd:string |
| http://purl.uniprot.org/citations/27932517 | http://purl.uniprot.org/core/author | "Kubo M."xsd:string |
| http://purl.uniprot.org/citations/27932517 | http://purl.uniprot.org/core/author | "Miyake S."xsd:string |
| http://purl.uniprot.org/citations/27932517 | http://purl.uniprot.org/core/author | "Shibuya A."xsd:string |
| http://purl.uniprot.org/citations/27932517 | http://purl.uniprot.org/core/author | "Tahara-Hanaoka S."xsd:string |
| http://purl.uniprot.org/citations/27932517 | http://purl.uniprot.org/core/author | "Shibayama S."xsd:string |
| http://purl.uniprot.org/citations/27932517 | http://purl.uniprot.org/core/author | "Tsurusaki S."xsd:string |
| http://purl.uniprot.org/citations/27932517 | http://purl.uniprot.org/core/author | "Shibagaki S."xsd:string |
| http://purl.uniprot.org/citations/27932517 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27932517 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/27932517 | http://purl.uniprot.org/core/pages | "605-609"xsd:string |
| http://purl.uniprot.org/citations/27932517 | http://purl.uniprot.org/core/title | "Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis."xsd:string |
| http://purl.uniprot.org/citations/27932517 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/27932517 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27932517 |
| http://purl.uniprot.org/citations/27932517 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27932517 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1N6-mappedCitation-27932517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27932517 |
| http://purl.uniprot.org/uniprot/#_A0A140T8Q6-mappedCitation-27932517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27932517 |
| http://purl.uniprot.org/uniprot/#_B7ZP19-mappedCitation-27932517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27932517 |
| http://purl.uniprot.org/uniprot/#_Q3TB92-mappedCitation-27932517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27932517 |
| http://purl.uniprot.org/uniprot/#_S4R1V2-mappedCitation-27932517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27932517 |
| http://purl.uniprot.org/uniprot/S4R1V2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27932517 |
| http://purl.uniprot.org/uniprot/A0A140T8Q6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27932517 |