| http://purl.uniprot.org/citations/27932573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27932573 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy is an intracellular degradation pathway whose levels are tightly controlled to secure cell homeostasis. Unc-51-like kinase 1 (ULK1) is a conserved serine-threonine kinase that plays a central role in the initiation of autophagy. Here, we report that upon autophagy progression, ULK1 protein levels are specifically down-regulated by the E3 ligase NEDD4L, which ubiquitylates ULK1 for degradation by the proteasome. However, whereas ULK1 protein is degraded, ULK1 mRNA is actively transcribed. Upon reactivation of mTOR-dependent protein synthesis, basal levels of ULK1 are promptly restored, but the activity of newly synthesized ULK1 is inhibited by mTOR. This prepares the cell for a new possible round of autophagy stimulation. Our results thus place NEDD4L and ULK1 in a key position to control oscillatory activation of autophagy during prolonged stress to keep the levels of this process under a safe and physiological threshold."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201605089"xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/author | "Rodolfo C."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/author | "Cecconi F."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/author | "Ciccosanti F."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/author | "Fimia G.M."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/author | "Antonioli M."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/author | "Bielli P."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/author | "Bonaldo P."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/author | "Campello S."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/author | "Carinci M."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/author | "Nazio F."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/author | "Strappazzon F."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/author | "Valacca C."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/author | "Sette C."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/pages | "841-856"xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/title | "Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation."xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://purl.uniprot.org/core/volume | "215"xsd:string |
| http://purl.uniprot.org/citations/27932573 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27932573 |
| http://purl.uniprot.org/citations/27932573 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27932573 |
| http://purl.uniprot.org/uniprot/#_O75385-mappedCitation-27932573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27932573 |
| http://purl.uniprot.org/uniprot/#_Q96PU5-mappedCitation-27932573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27932573 |