| http://purl.uniprot.org/citations/27974438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27974438 | http://www.w3.org/2000/01/rdf-schema#comment | "In Drosophila melanogaster larvae, the ring gland (RG) is a control center that orchestrates major developmental transitions. It is a composite organ, consisting of the prothoracic gland, the corpus allatum, and the corpora cardiaca, each of which synthesizes and secretes a different hormone. Until now, the RG's broader developmental roles beyond endocrine secretion have not been explored. RNA sequencing and analysis of a new transcriptome resource from D. melanogaster wandering third instar larval RGs has provided a fascinating insight into the diversity of developmental signaling in this organ. We have found strong enrichment of expression of two gene pathways not previously associated with the RG: immune response and fatty acid metabolism. We have also uncovered strong expression for many uncharacterized genes. Additionally, RNA interference against RG-enriched cytochrome p450s Cyp6u1 and Cyp6g2 produced a lethal ecdysone deficiency and a juvenile hormone deficiency, respectively, flagging a critical role for these genes in hormone synthesis. This transcriptome provides a valuable new resource for investigation of roles played by the RG in governing insect development."xsd:string |
| http://purl.uniprot.org/citations/27974438 | http://purl.org/dc/terms/identifier | "doi:10.1534/g3.116.037333"xsd:string |
| http://purl.uniprot.org/citations/27974438 | http://purl.uniprot.org/core/author | "Robin C."xsd:string |
| http://purl.uniprot.org/citations/27974438 | http://purl.uniprot.org/core/author | "Yang Y.T."xsd:string |
| http://purl.uniprot.org/citations/27974438 | http://purl.uniprot.org/core/author | "Batterham P."xsd:string |
| http://purl.uniprot.org/citations/27974438 | http://purl.uniprot.org/core/author | "Perry T."xsd:string |
| http://purl.uniprot.org/citations/27974438 | http://purl.uniprot.org/core/author | "Somers J."xsd:string |
| http://purl.uniprot.org/citations/27974438 | http://purl.uniprot.org/core/author | "Sztal T."xsd:string |
| http://purl.uniprot.org/citations/27974438 | http://purl.uniprot.org/core/author | "Christesen D."xsd:string |
| http://purl.uniprot.org/citations/27974438 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27974438 | http://purl.uniprot.org/core/name | "G3 (Bethesda)"xsd:string |
| http://purl.uniprot.org/citations/27974438 | http://purl.uniprot.org/core/pages | "467-479"xsd:string |
| http://purl.uniprot.org/citations/27974438 | http://purl.uniprot.org/core/title | "Transcriptome Analysis of Drosophila melanogaster Third Instar Larval Ring Glands Points to Novel Functions and Uncovers a Cytochrome p450 Required for Development."xsd:string |
| http://purl.uniprot.org/citations/27974438 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27974438 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27974438 |
| http://purl.uniprot.org/citations/27974438 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27974438 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHQ0-mappedCitation-27974438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27974438 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHY4-mappedCitation-27974438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27974438 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LET2-mappedCitation-27974438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27974438 |
| http://purl.uniprot.org/uniprot/#_A0A0S0WMR4-mappedCitation-27974438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27974438 |
| http://purl.uniprot.org/uniprot/#_E1JHK1-mappedCitation-27974438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27974438 |
| http://purl.uniprot.org/uniprot/#_E1JHK2-mappedCitation-27974438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27974438 |
| http://purl.uniprot.org/uniprot/#_Q1JUZ1-mappedCitation-27974438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27974438 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K885-mappedCitation-27974438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27974438 |