| http://purl.uniprot.org/citations/27979921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27979921 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial cytochrome c oxidase (CcO) transfers electrons from cytochrome c (Cyt.c) to O2 to generate H2O, a process coupled to proton pumping. To elucidate the mechanism of electron transfer, we determined the structure of the mammalian Cyt.c-CcO complex at 2.0-Å resolution and identified an electron transfer pathway from Cyt.c to CcO. The specific interaction between Cyt.c and CcO is stabilized by a few electrostatic interactions between side chains within a small contact surface area. Between the two proteins are three water layers with a long inter-molecular span, one of which lies between the other two layers without significant direct interaction with either protein. Cyt.c undergoes large structural fluctuations, using the interacting regions with CcO as a fulcrum. These features of the protein-protein interaction at the docking interface represent the first known example of a new class of protein-protein interaction, which we term "soft and specific". This interaction is likely to contribute to the rapid association/dissociation of the Cyt.c-CcO complex, which facilitates the sequential supply of four electrons for the O2 reduction reaction."xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201695021"xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/author | "Kang J."xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/author | "Tsukihara T."xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/author | "Yamashita E."xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/author | "Tateno M."xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/author | "Shimada A."xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/author | "Yoshikawa S."xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/author | "Shimada S."xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/author | "Baba J."xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/author | "Shinzawa-Itoh K."xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/author | "Aoe S."xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/pages | "291-300"xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/title | "Complex structure of cytochrome c-cytochrome c oxidase reveals a novel protein-protein interaction mode."xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/27979921 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27979921 |
| http://purl.uniprot.org/citations/27979921 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27979921 |
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| http://purl.uniprot.org/uniprot/#_P10175-mappedCitation-27979921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27979921 |
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| http://purl.uniprot.org/uniprot/#_P00396-mappedCitation-27979921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27979921 |
| http://purl.uniprot.org/uniprot/#_P00415-mappedCitation-27979921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27979921 |