| http://purl.uniprot.org/citations/27984725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27984725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27984725 | http://www.w3.org/2000/01/rdf-schema#comment | "S phase and mitotic onset are brought about by the action of multiple different cyclin-CDK complexes. However, it has been suggested that changes in the total level of CDK kinase activity, rather than substrate specificity, drive the temporal ordering of S phase and mitosis. Here, we present a phosphoproteomics-based systems analysis of CDK substrates in fission yeast and demonstrate that the phosphorylation of different CDK substrates can be temporally ordered during the cell cycle by a single cyclin-CDK. This is achieved by rising CDK activity and the differential sensitivity of substrates to CDK activity over a wide dynamic range. This is combined with rapid phosphorylation turnover to generate clearly resolved substrate-specific activity thresholds, which in turn ensures the appropriate ordering of downstream cell-cycle events. Comparative analysis with wild-type cells expressing multiple cyclin-CDK complexes reveals how cyclin-substrate specificity works alongside activity thresholds to fine-tune the patterns of substrate phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2016.11.034"xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2016.11.034"xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/author | "Snijders A.P."xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/author | "Snijders A.P."xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/author | "Nurse P."xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/author | "Nurse P."xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/author | "Flynn H.R."xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/author | "Flynn H.R."xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/author | "Jones A.W."xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/author | "Jones A.W."xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/author | "Swaffer M.P."xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/author | "Swaffer M.P."xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/pages | "1750-1761"xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/pages | "1750-1761"xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/title | "CDK Substrate Phosphorylation and Ordering the Cell Cycle."xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/title | "CDK Substrate Phosphorylation and Ordering the Cell Cycle."xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/volume | "167"xsd:string |
| http://purl.uniprot.org/citations/27984725 | http://purl.uniprot.org/core/volume | "167"xsd:string |