| http://purl.uniprot.org/citations/27993576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27993576 | http://www.w3.org/2000/01/rdf-schema#comment | "Synovial sarcoma (SS) is regarded as a relatively chemosensitive sarcoma, but the prognosis of advanced SSs remains poor. Here we identified highly expressed cancer-testis antigens that could be promising immunotherapy targets for SS, using a previously conducted cDNA microarray, and we assessed the clinicopathological or prognostic relationships of these antigens in SS. We compared the gene expression profiles of 11 SSs with those of 3 normal adipose tissues. Among the up-regulated cancer-testis antigens, we analyzed PRAME, MAGEA1, and MAGEA4 and another cancer-testis antigen (NY-ESO-1) together, by immunohistochemistry and real-time polymerase chain reaction in 108 SSs. Immunohistochemically, NY-ESO-1, PRAME, MAGEA4, and MAGEA1 were positive in 66 (61%), 93 (86%), 89 (82%), and 16 (15%) of 108 SSs, respectively, and 104 (96%) of 108 SSs showed the immunohistochemical expression of at least 1 of NY-ESO-1, PRAME, and MAGEA4. Moreover, the high expression of at least 1 of these 3 antigens was observed in 83% of the SSs. High expression of NY-ESO-1 and MAGEA4 was significantly correlated with the presence of necrosis and advanced clinical stage. The immunohistochemical expression of these cancer-testis antigens was not correlated with prognosis, but the coexpression of NY-ESO-1, PRAME, and MAGEA4 was significantly associated with adverse prognosis. The real-time polymerase chain reaction results were closely related to the immunohistochemical results: NY-ESO-1 (P = .0019), PRAME (P = .039), MAGEA4 (P = .0149), and MAGEA1 (P = .0766). These data support the potential utility of NY-ESO-1, PRAME, and MAGEA4 as immunotherapy targets and ancillary prognostic parameters, suggesting the possible benefit of the combined use of these cancer-testis antigens as an SS immunotherapy target."xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humpath.2016.12.006"xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/author | "Iwamoto Y."xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/author | "Oda Y."xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/author | "Yamada Y."xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/author | "Yamamoto H."xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/author | "Ishii T."xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/author | "Otsuka H."xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/author | "Maekawa A."xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/author | "Kohashi K."xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/author | "Bekki H."xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/author | "Iura K."xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/author | "Harimaya K."xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/name | "Hum Pathol"xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/pages | "130-139"xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/title | "Cancer-testis antigen expression in synovial sarcoma: NY-ESO-1, PRAME, MAGEA4, and MAGEA1."xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://purl.uniprot.org/core/volume | "61"xsd:string |
| http://purl.uniprot.org/citations/27993576 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27993576 |
| http://purl.uniprot.org/citations/27993576 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27993576 |
| http://purl.uniprot.org/uniprot/#_A8IF97-mappedCitation-27993576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27993576 |
| http://purl.uniprot.org/uniprot/#_B7Z7K8-mappedCitation-27993576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27993576 |
| http://purl.uniprot.org/uniprot/#_B4DTE6-mappedCitation-27993576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27993576 |
| http://purl.uniprot.org/uniprot/#_B7Z986-mappedCitation-27993576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27993576 |