| http://purl.uniprot.org/citations/27996004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27996004 | http://www.w3.org/2000/01/rdf-schema#comment | "The transforming growth factor β (TGFβ) pathway plays critical roles during cancer cell epithelial-mesenchymal transition (EMT) and metastasis. SMAD7 is both a transcriptional target and a negative regulator of TGFβ signalling, thus mediating a negative feedback loop that may potentially restrain TGFβ responses of cancer cells. Here, however, we show that TGFβ treatment induces SMAD7 transcription but not its protein level in a panel of cancer cells. Mechanistic studies reveal that TGFβ activates the expression of microRNA-182 (miR-182), which suppresses SMAD7 protein. miR-182 silencing leads to SMAD7 upregulation on TGFβ treatment and prevents TGFβ-induced EMT and invasion of cancer cells. Overexpression of miR-182 promotes breast tumour invasion and TGFβ-induced osteoclastogenesis for bone metastasis. Furthermore, miR-182 expression inversely correlates with SMAD7 protein in human tumour samples. Therefore, our data reveal the miR-182-mediated disruption of TGFβ self-restraint and provide a mechanism to explain the unleashed TGFβ responses in metastatic cancer cells."xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms13884"xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://purl.uniprot.org/core/author | "Hu G."xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://purl.uniprot.org/core/author | "Lei R."xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://purl.uniprot.org/core/author | "Zhuang X."xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://purl.uniprot.org/core/author | "Lev S."xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://purl.uniprot.org/core/author | "Segura M.F."xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27996004 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://purl.uniprot.org/core/pages | "13884"xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://purl.uniprot.org/core/title | "MicroRNA-182 targets SMAD7 to potentiate TGFbeta-induced epithelial-mesenchymal transition and metastasis of cancer cells."xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27996004 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27996004 |
| http://purl.uniprot.org/citations/27996004 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27996004 |
| http://purl.uniprot.org/uniprot/#_A0A078BBI5-mappedCitation-27996004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996004 |
| http://purl.uniprot.org/uniprot/#_A0A078BC11-mappedCitation-27996004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996004 |
| http://purl.uniprot.org/uniprot/#_A0A078BCJ0-mappedCitation-27996004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996004 |
| http://purl.uniprot.org/uniprot/#_A0A078BCH8-mappedCitation-27996004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996004 |
| http://purl.uniprot.org/uniprot/#_A0A078BFK3-mappedCitation-27996004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996004 |
| http://purl.uniprot.org/uniprot/#_A0A510GAF6-mappedCitation-27996004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996004 |