| http://purl.uniprot.org/citations/27996172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27996172 | http://www.w3.org/2000/01/rdf-schema#comment | "PICT-1 is a nucleolar protein with various tumor suppressor functions. Recently, PICT-1 expression was reported to be dramatically reduced in several cancers. To investigate the role of PICT-1 in uterine cervical carcinogenesis, we examined its gene mutations, protein expression, cellular localization, and effect on p53 stabilization. PCR-SSCP analysis of the entire coding region of PICT-1 showed that a polymorphism at codon 389 may increase the risk of uterine cervical cancers, and also identified a novel missense mutation. Expression of wild-type PICT-1 inhibited the degradation of p53 in the presence or absence of HPV 18 E6 viral protein in vitro, while the expression of codon 389 polymorphic PICT-1 had a diminished inhibitory effect on p53 degradation. Moreover, we observed that PICT-1 degradation was induced both independently and cooperatively by E6 and E7 proteins from high-risk HPVs, but only marginal degradation was observed with proteins from low-risk HPV. Immunohistochemical staining of tumor samples revealed that lower levels of PICT-1 were observed in samples from CIN III and cervical cancer tissues, compared to normal cervical epithelium and CIN I, II tissues (Pā<ā0.05). The reduction of PICT-1 may therefore be an early event in uterine cervical tumorigenesis. Our results indicated that PICT-1 counteracts HPV-induced p53 degradation and that aberrant PICT-1 function may contribute towards inactivating p53. Therefore, PICT-1 may play a critical role during the pathogenesis of uterine cervical cancers."xsd:string |
| http://purl.uniprot.org/citations/27996172 | http://purl.org/dc/terms/identifier | "doi:10.1002/mc.22608"xsd:string |
| http://purl.uniprot.org/citations/27996172 | http://purl.uniprot.org/core/author | "Yoshimoto M."xsd:string |
| http://purl.uniprot.org/citations/27996172 | http://purl.uniprot.org/core/author | "Nishiwaki K."xsd:string |
| http://purl.uniprot.org/citations/27996172 | http://purl.uniprot.org/core/author | "Sengoku K."xsd:string |
| http://purl.uniprot.org/citations/27996172 | http://purl.uniprot.org/core/author | "Yaginuma Y."xsd:string |
| http://purl.uniprot.org/citations/27996172 | http://purl.uniprot.org/core/author | "Tokuda A."xsd:string |
| http://purl.uniprot.org/citations/27996172 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27996172 | http://purl.uniprot.org/core/name | "Mol Carcinog"xsd:string |
| http://purl.uniprot.org/citations/27996172 | http://purl.uniprot.org/core/pages | "1484-1492"xsd:string |
| http://purl.uniprot.org/citations/27996172 | http://purl.uniprot.org/core/title | "The protein interacting with carboxyl terminus-1 codon 389 polymorphism impairs protein interacting with carboxyl terminus-1 function and is a risk factor for uterine cervical cancer."xsd:string |
| http://purl.uniprot.org/citations/27996172 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/27996172 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27996172 |
| http://purl.uniprot.org/citations/27996172 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27996172 |
| http://purl.uniprot.org/uniprot/#_B4DVK1-mappedCitation-27996172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996172 |
| http://purl.uniprot.org/uniprot/#_B4DND9-mappedCitation-27996172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996172 |
| http://purl.uniprot.org/uniprot/#_B4E1N4-mappedCitation-27996172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996172 |
| http://purl.uniprot.org/uniprot/#_Q7L4X7-mappedCitation-27996172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996172 |
| http://purl.uniprot.org/uniprot/#_Q53YP0-mappedCitation-27996172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996172 |
| http://purl.uniprot.org/uniprot/#_Q9NZM5-mappedCitation-27996172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996172 |
| http://purl.uniprot.org/uniprot/#_Q96CS0-mappedCitation-27996172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996172 |
| http://purl.uniprot.org/uniprot/#_Q9H7J4-mappedCitation-27996172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996172 |
| http://purl.uniprot.org/uniprot/#_Q9P0B0-mappedCitation-27996172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27996172 |
| http://purl.uniprot.org/uniprot/B4DVK1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27996172 |