| http://purl.uniprot.org/citations/27997825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27997825 | http://www.w3.org/2000/01/rdf-schema#comment | "Cells dynamically interact throughout animal development to coordinate growth and deter disease. For example, cell-cell competition weeds out aberrant cells to enforce homeostasis. In Drosophila, tumorigenic cells mutant for the cell polarity gene scribble (scrib) are actively eliminated from epithelia when surrounded by wild-type cells. While scrib cell elimination depends critically on JNK signaling, JNK-dependent cell death cannot sufficiently explain scrib cell extirpation. Thus, how JNK executed cell elimination remained elusive. Here, we show that repulsive Slit-Robo2-Ena signaling exerts an extrusive force downstream of JNK to eliminate scrib cells from epithelia by disrupting E-cadherin. While loss of Slit-Robo2-Ena in scrib cells potentiates scrib tumor formation within the epithelium, Robo2-Ena hyperactivation surprisingly triggers luminal scrib tumor growth following excess extrusion. This extrusive signaling is amplified by a positive feedback loop between Slit-Robo2-Ena and JNK. Our observations provide a potential causal mechanism for Slit-Robo dysregulation in numerous human cancers."xsd:string |
| http://purl.uniprot.org/citations/27997825 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2016.11.015"xsd:string |
| http://purl.uniprot.org/citations/27997825 | http://purl.uniprot.org/core/author | "Igaki T."xsd:string |
| http://purl.uniprot.org/citations/27997825 | http://purl.uniprot.org/core/author | "Vaughen J."xsd:string |
| http://purl.uniprot.org/citations/27997825 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27997825 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/27997825 | http://purl.uniprot.org/core/pages | "683-695"xsd:string |
| http://purl.uniprot.org/citations/27997825 | http://purl.uniprot.org/core/title | "Slit-Robo Repulsive Signaling Extrudes Tumorigenic Cells from Epithelia."xsd:string |
| http://purl.uniprot.org/citations/27997825 | http://purl.uniprot.org/core/volume | "39"xsd:string |
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