| http://purl.uniprot.org/citations/27998980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27998980 | http://www.w3.org/2000/01/rdf-schema#comment | "The interaction of glutamate and dopamine in the striatum is heavily dependent on signaling pathways that converge on the regulatory protein DARPP-32. The efficacy of dopamine/D1 receptor/PKA signaling is regulated by DARPP-32 phosphorylated at Thr-34 (the PKA site), a process that inhibits protein phosphatase 1 (PP1) and potentiates PKA action. Activation of dopamine/D1 receptor/PKA signaling also leads to dephosphorylation of DARPP-32 at Ser-97 (the CK2 site), leading to localization of phospho-Thr-34 DARPP-32 in the nucleus where it also inhibits PP1. In this study the role of glutamate in the regulation of DARPP-32 phosphorylation at four major sites was further investigated. Experiments using striatal slices revealed that glutamate decreased the phosphorylation states of DARPP-32 at Ser-97 as well as Thr-34, Thr-75, and Ser-130 by activating NMDA or AMPA receptors in both direct and indirect pathway striatal neurons. The effect of glutamate in decreasing Ser-97 phosphorylation was mediated by activation of PP2A. In vitro phosphatase assays indicated that the PP2A/PR72 heterotrimer complex was likely responsible for glutamate/Ca2+-regulated dephosphorylation of DARPP-32 at Ser-97. As a consequence of Ser-97 dephosphorylation, glutamate induced the nuclear localization in cultured striatal neurons of dephospho-Thr-34/dephospho-Ser-97 DARPP-32. It also reduced PKA-dependent DARPP-32 signaling in slices and in vivo Taken together, the results suggest that by inducing dephosphorylation of DARPP-32 at Ser-97 and altering its cytonuclear distribution, glutamate may counteract dopamine/D1 receptor/PKA signaling at multiple cellular levels."xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m116.752402"xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/author | "Valjent E."xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/author | "Nishi A."xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/author | "Greengard P."xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/author | "Nairn A.C."xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/author | "Kuroiwa M."xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/author | "Girault J.A."xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/author | "Rebholz H."xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/author | "Kitahara Y."xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/author | "Musante V."xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/author | "Matamales M."xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/pages | "1462-1476"xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/title | "Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution."xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://purl.uniprot.org/core/volume | "292"xsd:string |
| http://purl.uniprot.org/citations/27998980 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27998980 |
| http://purl.uniprot.org/citations/27998980 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27998980 |
| http://purl.uniprot.org/uniprot/O54833#attribution-7FE481E5B6C8688757DDD8DEB27A9163 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27998980 |
| http://purl.uniprot.org/uniprot/Q9Z176#attribution-7FE481E5B6C8688757DDD8DEB27A9163 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27998980 |
| http://purl.uniprot.org/uniprot/#_A0A087WQA6-mappedCitation-27998980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27998980 |
| http://purl.uniprot.org/uniprot/#_A0A087WP99-mappedCitation-27998980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27998980 |
| http://purl.uniprot.org/uniprot/#_A0A087WS63-mappedCitation-27998980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27998980 |