| http://purl.uniprot.org/citations/28002730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28002730 | http://www.w3.org/2000/01/rdf-schema#comment | "Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alveolar macrophages (AMs), which then released interleukin-1α (IL-1α) and caused inducible bronchus-associated lymphoid tissue (iBALT) formation in the lung. IL-1α release continued for up to 2 weeks after particulate exposure, and type-2 allergic immune responses were induced by the inhalation of antigen during IL-1α release and iBALT formation, even long after particulate instillation. Recombinant IL-1α was sufficient to induce iBALTs, which coincided with subsequent immunoglobulin E responses, and IL-1-receptor-deficient mice failed to induce iBALT formation. Therefore, the AM-IL-1α-iBALT axis might be a therapeutic target for particulate-induced allergic inflammation."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2016.11.010"xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Horie M."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Hayashi M."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Morimoto Y."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Kurosaki T."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Kusakabe T."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Nakajima S."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Kunisawa J."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Ishii K.J."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Kobiyama K."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Nagatake T."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Aoshi T."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Ise W."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Ziegler S.F."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Uematsu S."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Takemura N."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Coban C."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Ozasa K."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Kabashima K."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Kuroda E."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Ohata K."xsd:string |
| http://purl.uniprot.org/citations/28002730 | http://purl.uniprot.org/core/author | "Kanuma T."xsd:string |