| http://purl.uniprot.org/citations/28002805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28002805 | http://www.w3.org/2000/01/rdf-schema#comment | "AimsPSMA (prostate specific membrane antigen) is physiologically expressed in normal prostate tissue. It is overexpressed in prostate cancer cells and has been suggested as a target for antibody-based radioligand therapy. As PSMA expression so far has not been systematically analyzed in soft tissue tumors, the current study aims at investigating a large cohort of different subtypes.Methods and resultsImmunohistochemistry was used to detect PSMA expression in 779 samples of soft tissue tumors and Ewing sarcoma as a primary bone malignancy. CD34 coexpression was employed to study PSMA expression in the neovasculature. PSMA expression was found in the tumor-associated neovasculature of 151/779 soft tissue/bone tumors (19.38%) and was more frequent in malignant tumors compared to tumors with intermediate or benign biological potential (p=0.078). Strong neovascular PSMA expression was predominantly observed in subsets of different sarcomas including 3/20 rhabdomyosarcomas (15%), 4/21 malignant peripheral nerve sheath tumors (19.05%), 6/16 synovial sarcomas (35.29%) and 6/33 undifferentiated pleomorphic sarcomas (18.18%).ConclusionWe conclude that PSMA is expressed in the neovasculature of a subset of soft tissue tumors to a variable extent. Our observation of strong PSMA expression predominantly occurring in sarcomas might provide a rationale to evaluate PSMA-targeted radioligand therapy in these entities."xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.13994"xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/author | "Huss S."xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/author | "Grunewald I."xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/author | "Hartmann W."xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/author | "Wardelmann E."xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/author | "Bogemann M."xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/author | "Gevensleben H."xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/author | "Trautmann M."xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/author | "Steinestel K."xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/author | "Rahbar K."xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/author | "Heitkotter B."xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/pages | "4268-4276"xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/title | "Expression of PSMA in tumor neovasculature of high grade sarcomas including synovial sarcoma, rhabdomyosarcoma, undifferentiated sarcoma and MPNST."xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/28002805 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28002805 |
| http://purl.uniprot.org/citations/28002805 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28002805 |
| http://purl.uniprot.org/uniprot/#_A4UU13-mappedCitation-28002805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28002805 |
| http://purl.uniprot.org/uniprot/#_B7Z6L3-mappedCitation-28002805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28002805 |
| http://purl.uniprot.org/uniprot/#_Q04609-mappedCitation-28002805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28002805 |
| http://purl.uniprot.org/uniprot/#_Q2VPJ0-mappedCitation-28002805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28002805 |
| http://purl.uniprot.org/uniprot/#_Q7Z5D2-mappedCitation-28002805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28002805 |