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http://purl.uniprot.org/citations/28004973http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28004973http://www.w3.org/2000/01/rdf-schema#comment"

Context

Von Hippel-Lindau disease (VHLD) is a rare inherited neoplastic syndrome. Among all the VHLD-associated tumors, clear cell renal cell carcinoma (ccRCC) is the major cause of death.

Objective

The aim of this paper is the discovery of new non-invasive biomarker for the monitoring of VHLD patients.

Materials and methods

We compared the urinary proteome of VHLD patients, ccRCC patients and healthy volunteers.

Results

Among all differentially expressed proteins, alpha-1-antitrypsin (A1AT) and APOH (beta-2-glycoprotein-1) are strongly over-abundant only in the urine of VHLD patients with a history of ccRCC.

Discussion and conclusion

A1AT and APOH could be promising non-invasive biomarkers."xsd:string
http://purl.uniprot.org/citations/28004973http://purl.org/dc/terms/identifier"doi:10.1080/1354750x.2016.1269132"xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/author"Battaglia A."xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/author"Novelli F."xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/author"Turrini F."xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/author"Giribaldi G."xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/author"Mandili G."xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/author"Destefanis P."xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/author"Khadjavi A."xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/author"Allasia M."xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/author"Frea B."xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/author"Notarpietro A."xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/author"Lucatello B."xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/name"Biomarkers"xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/pages"123-130"xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/title"Beta-2-glycoprotein-1 and alpha-1-antitrypsin as urinary markers of renal cancer in von Hippel-Lindau patients."xsd:string
http://purl.uniprot.org/citations/28004973http://purl.uniprot.org/core/volume"23"xsd:string
http://purl.uniprot.org/citations/28004973http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/28004973
http://purl.uniprot.org/citations/28004973http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/28004973
http://purl.uniprot.org/uniprot/#_A0A024R6N5-mappedCitation-28004973http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28004973
http://purl.uniprot.org/uniprot/#_A0A0S2Z465-mappedCitation-28004973http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28004973
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http://purl.uniprot.org/uniprot/#_A6YP93-mappedCitation-28004973http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28004973