| http://purl.uniprot.org/citations/28008933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28008933 | http://www.w3.org/2000/01/rdf-schema#comment | "CCR5 stimulation with natural ligands, such as RANTES, classically induces short-term internalization with transient activation of β-arrestins and rapidly recycling on the cell surface. Here we discovered that, in T cells, natural CCR5 antibodies induce a CCR5-negative phenotype with the involvement of β-arrestin2, which leads to the formation of a stable CCR5 signalosome with both β-arrestin2 and ERK1. The activation of β-arrestin2 is necessary to CCR5 signaling for the signalosome formation and stabilization. When all stimuli were washed out, β-arrestin1 silencing favors the activity of β-arrestin2 for the CCR5 signalosome retention. Interestingly, CCR5 turn from Class A trafficking pattern, normally used for its internalization with natural modulating molecules (i.e. RANTES), into a long lasting Class B type specifically induced by stimulation with natural anti-CCR5 antibodies. This new CCR5 pathway is relevant not only to study in depth the molecular basis of all pathologies where CCR5 is involved but also to generate new antidody-based therapeutics."xsd:string |
| http://purl.uniprot.org/citations/28008933 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep39382"xsd:string |
| http://purl.uniprot.org/citations/28008933 | http://purl.uniprot.org/core/author | "Riva A."xsd:string |
| http://purl.uniprot.org/citations/28008933 | http://purl.uniprot.org/core/author | "Lopalco L."xsd:string |
| http://purl.uniprot.org/citations/28008933 | http://purl.uniprot.org/core/author | "Pastori C."xsd:string |
| http://purl.uniprot.org/citations/28008933 | http://purl.uniprot.org/core/author | "Venuti A."xsd:string |
| http://purl.uniprot.org/citations/28008933 | http://purl.uniprot.org/core/author | "Sciortino M.T."xsd:string |
| http://purl.uniprot.org/citations/28008933 | http://purl.uniprot.org/core/author | "Pennisi R."xsd:string |
| http://purl.uniprot.org/citations/28008933 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/28008933 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28008933 | http://purl.uniprot.org/core/pages | "39382"xsd:string |
| http://purl.uniprot.org/citations/28008933 | http://purl.uniprot.org/core/title | "Class B beta-arrestin2-dependent CCR5 signalosome retention with natural antibodies to CCR5."xsd:string |
| http://purl.uniprot.org/citations/28008933 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/28008933 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28008933 |
| http://purl.uniprot.org/citations/28008933 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28008933 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S6-mappedCitation-28008933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28008933 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S9-mappedCitation-28008933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28008933 |
| http://purl.uniprot.org/uniprot/#_A0A089G7F7-mappedCitation-28008933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28008933 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G0-mappedCitation-28008933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28008933 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G7-mappedCitation-28008933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28008933 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G9-mappedCitation-28008933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28008933 |
| http://purl.uniprot.org/uniprot/#_A0A089G3J8-mappedCitation-28008933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28008933 |
| http://purl.uniprot.org/uniprot/#_A0A089G3N4-mappedCitation-28008933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28008933 |
| http://purl.uniprot.org/uniprot/#_A0A089G3P0-mappedCitation-28008933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28008933 |