| http://purl.uniprot.org/citations/28009292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28009292 | http://www.w3.org/2000/01/rdf-schema#comment | "Neural circuits involving midbrain dopaminergic (DA) neurons regulate reward and goal-directed behaviors. Although local GABAergic input is known to modulate DA circuits, the mechanism that controls excitatory/inhibitory synaptic balance in DA neurons remains unclear. Here, we show that DA neurons use autocrine transforming growth factor β (TGF-β) signaling to promote the growth of axons and dendrites. Surprisingly, removing TGF-β type II receptor in DA neurons also disrupts the balance in TGF-β1 expression in DA neurons and neighboring GABAergic neurons, which increases inhibitory input, reduces excitatory synaptic input, and alters phasic firing patterns in DA neurons. Mice lacking TGF-β signaling in DA neurons are hyperactive and exhibit inflexibility in relinquishing learned behaviors and re-establishing new stimulus-reward associations. These results support a role for TGF-β in regulating the delicate balance of excitatory/inhibitory synaptic input in local microcircuits involving DA and GABAergic neurons and its potential contributions to neuropsychiatric disorders."xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.11.068"xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://purl.uniprot.org/core/author | "Shang Y."xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://purl.uniprot.org/core/author | "Kim J.I."xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://purl.uniprot.org/core/author | "Whistler J.L."xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://purl.uniprot.org/core/author | "Ding J.B."xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://purl.uniprot.org/core/author | "Huang E.J."xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://purl.uniprot.org/core/author | "Luo S.X."xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://purl.uniprot.org/core/author | "Tang A.A."xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://purl.uniprot.org/core/author | "Sandoval K."xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://purl.uniprot.org/core/author | "Timbang L."xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/28009292 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://purl.uniprot.org/core/pages | "3233-3245"xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://purl.uniprot.org/core/title | "TGF-beta Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning."xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/28009292 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28009292 |
| http://purl.uniprot.org/citations/28009292 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28009292 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXU9-mappedCitation-28009292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28009292 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0A6-mappedCitation-28009292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28009292 |
| http://purl.uniprot.org/uniprot/#_E9Q9G5-mappedCitation-28009292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28009292 |
| http://purl.uniprot.org/uniprot/#_A0A140LHC9-mappedCitation-28009292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28009292 |
| http://purl.uniprot.org/uniprot/#_D3Z1L8-mappedCitation-28009292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28009292 |
| http://purl.uniprot.org/uniprot/#_D3Z5S3-mappedCitation-28009292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28009292 |