| http://purl.uniprot.org/citations/28009301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28009301 | http://www.w3.org/2000/01/rdf-schema#comment | "Anti-apoptotic BCL-2 family members bind to BH3-only proteins and multidomain BAX/BAK to preserve mitochondrial integrity and maintain survival. Whereas inhibition of these interactions is the biological basis of BH3-mimetic anti-cancer therapy, the actual response of membrane-bound protein complexes to these compounds is currently ill-defined. Here, we find that treatment with BH3 mimetics targeting BCL-xL spares subsets of cells with the highest levels of this protein. In intact cells, sequestration of some pro-apoptotic activators (including PUMA and BIM) by full-length BCL-xL is much more resistant to derepression than previously described in cell-free systems. Alterations in the BCL-xL C-terminal anchor that impacts subcellular membrane-targeting and localization dynamics restore sensitivity. Thus, the membrane localization of BCL-xL enforces its control over cell survival and, importantly, limits the pro-apoptotic effects of BH3 mimetics by selectively influencing BCL-xL binding to key pro-apoptotic effectors."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.11.064"xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/author | "Braun F."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/author | "Letai A."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/author | "Sarosiek K.A."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/author | "Maillet L."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/author | "Gautier F."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/author | "Le Pen J."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/author | "Bock F.J."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/author | "Vuillier C."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/author | "Fetiveau A."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/author | "Juin P.P."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/author | "Pecot J."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/author | "Tait S.W.G."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/author | "Trecesson S.C."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/pages | "3347-3358"xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/title | "Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance."xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/28009301 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28009301 |
| http://purl.uniprot.org/citations/28009301 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28009301 |
| http://purl.uniprot.org/uniprot/#_B4DZQ9-mappedCitation-28009301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28009301 |
| http://purl.uniprot.org/uniprot/#_Q92934-mappedCitation-28009301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28009301 |