| http://purl.uniprot.org/citations/28011866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28011866 | http://www.w3.org/2000/01/rdf-schema#comment | "Generation of cellular heterogeneity is an essential feature of the adaptive immune system. This is best exemplified during humoral immune response when an expanding B cell clone assumes multiple cell fates, including class-switched B cells, antibody-secreting plasma cells, and memory B cells. Although each cell type is essential for immunity, their generation must be exquisitely controlled because a class-switched B cell cannot revert back to the parent isotype, and a terminally differentiated plasma cell cannot contribute to the memory pool. In this study, we show that an environmental sensor, the aryl hydrocarbon receptor (AhR) is highly induced upon B cell activation and serves a critical role in regulating activation-induced cell fate outcomes. We find that AhR negatively regulates class-switch recombination ex vivo by altering activation-induced cytidine deaminase expression. We further demonstrate that AhR suppresses class switching in vivo after influenza virus infection and immunization with model antigens. In addition, by regulating Blimp-1 expression via Bach2, AhR represses differentiation of B cells into plasmablasts ex vivo and antibody-secreting plasma cells in vivo. These experiments suggest that AhR serves as a molecular rheostat in B cells to brake the effector response, possibly to facilitate optimal recall responses. Thus, AhR might represent a novel molecular target for manipulation of B cell responses during vaccination."xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20160789"xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/author | "McDermott A.B."xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/author | "Wheatley A.K."xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/author | "Yewdell J.W."xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/author | "Chaudhry A."xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/author | "Bradfield C.A."xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/author | "Chaudhuri J."xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/author | "Yewdell W.T."xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/author | "Rudensky A.Y."xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/author | "Angeletti D."xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/author | "Vaidyanathan B."xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/author | "Yen W.F."xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/pages | "197-208"xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/title | "The aryl hydrocarbon receptor controls cell-fate decisions in B cells."xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://purl.uniprot.org/core/volume | "214"xsd:string |
| http://purl.uniprot.org/citations/28011866 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28011866 |
| http://purl.uniprot.org/citations/28011866 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28011866 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1L1-mappedCitation-28011866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28011866 |
| http://purl.uniprot.org/uniprot/#_Q3U2B1-mappedCitation-28011866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28011866 |
| http://purl.uniprot.org/uniprot/#_P30561-mappedCitation-28011866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28011866 |
| http://purl.uniprot.org/uniprot/#_Q3U5D9-mappedCitation-28011866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28011866 |