| http://purl.uniprot.org/citations/28011934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28011934 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of IL-33, particularly in tumor growth and tumor immunity, remains ill-defined. We show that exogenous IL-33 can induce robust antitumor effect through a CD8+ T cell-dependent mechanism. Systemic administration of rIL-33 alone was sufficient to inhibit growth of established tumors in transplant and de novo melanoma tumorigenesis models. Notably, in addition to a direct action on CD8+ T cell expansion and IFN-γ production, rIL-33 therapy activated myeloid dendritic cells (mDCs) in tumor-bearing mice, restored antitumor T cell activity, and increased Ag cross-presentation within the tumor microenvironment. Furthermore, combination therapy consisting of rIL-33 and agonistic anti-CD40 Abs demonstrated synergistic antitumor activity. Specifically, MyD88, an essential component of the IL-33 signaling pathway, was required for the IL-33-mediated increase in mDC number and upregulation in expression of costimulatory molecules. Importantly, we identified that the IL-33 receptor ST2, MyD88, and STAT1 cooperate to induce costimulatory molecule expression on mDCs in response to rIL-33. Thus, our study revealed a novel IL-33-ST2-MyD88-STAT1 axis that restores mDC activation and maturation in established cancer and, thereby, the magnitude of antitumor immune responses, suggesting a potential use of rIL-33 as a new immunotherapy option to treat established cancer."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1501399"xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/author | "Fan J."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/author | "Long A."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/author | "Ye C."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/author | "Zhang B."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/author | "Fang D."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/author | "Qin L."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/author | "Dominguez D."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/author | "Geng Z."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/author | "Kuzel T.M."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/pages | "1365-1375"xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/title | "Exogenous IL-33 Restores Dendritic Cell Activation and Maturation in Established Cancer."xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://purl.uniprot.org/core/volume | "198"xsd:string |
| http://purl.uniprot.org/citations/28011934 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28011934 |
| http://purl.uniprot.org/citations/28011934 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28011934 |
| http://purl.uniprot.org/uniprot/#_A0A024QYR9-mappedCitation-28011934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28011934 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-28011934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28011934 |