| http://purl.uniprot.org/citations/28017375 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28017375 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28017375 | http://www.w3.org/2000/01/rdf-schema#comment | "Genome-wide association studies (GWASs) have identified loci for erythrocyte traits in primarily European ancestry populations. We conducted GWAS meta-analyses of six erythrocyte traits in 71,638 individuals from European, East Asian, and African ancestries using a Bayesian approach to account for heterogeneity in allelic effects and variation in the structure of linkage disequilibrium between ethnicities. We identified seven loci for erythrocyte traits including a locus (RBPMS/GTF2E2) associated with mean corpuscular hemoglobin and mean corpuscular volume. Statistical fine-mapping at this locus pointed to RBPMS at this locus and excluded nearby GTF2E2. Using zebrafish morpholino to evaluate loss of function, we observed a strong in vivo erythropoietic effect for RBPMS but not for GTF2E2, supporting the statistical fine-mapping at this locus and demonstrating that RBPMS is a regulator of erythropoiesis. Our findings show the utility of trans-ethnic GWASs for discovery and characterization of genetic loci influencing hematologic traits."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ajhg.2016.11.016"xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Chen C.H."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Chen C.H."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Hayes J."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Hayes J."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Hu B."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Hu B."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Longo D.L."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Longo D.L."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Kubo M."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Kubo M."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Okada Y."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Okada Y."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Schmidt R."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Schmidt R."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Tanaka T."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Tanaka T."xsd:string |
| http://purl.uniprot.org/citations/28017375 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |