| http://purl.uniprot.org/citations/28018171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28018171 | http://www.w3.org/2000/01/rdf-schema#comment | "In view of important neurobiological functions of the cell adhesion molecule contactin-6 (Cntn6) that have emerged from studies on null-mutant mice and autism spectrum disorders patients, we set out to examine pathways underlying functions of Cntn6 using a proteomics approach. We identified the cell adhesion GPCR latrophilin-1 (Lphn1, a.k.a. CIRL1/CL, ADGRL1) as a binding partner for Cntn6 forming together a heteromeric cis-complex. Lphn1 expression in cultured neurons caused reduction in neurite outgrowth and increase in apoptosis, which was rescued by coexpression of Cntn6. In cultured neurons derived from Cntn6-/- mice, Lphn1 knockdown reduced apoptosis, suggesting that the observed apoptosis was Lphn1-dependent. In line with these data, the number of apoptotic cells was increased in the cortex of Cntn6-/- mice compared to wild-type littermate controls. These results show that Cntn6 can modulate the activity of Lphn1 by direct binding and suggests that Cntn6 may prevent apoptosis thereby impinging on neurodevelopment."xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.org/dc/terms/identifier | "doi:10.3389/fnmol.2016.00143"xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/author | "Heck A.J."xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/author | "Pasterkamp R.J."xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/author | "Shimoda Y."xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/author | "Petrenko A.G."xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/author | "van der Zwaag B."xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/author | "Altelaar A.F."xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/author | "Post H."xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/author | "Burbach J.P."xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/author | "van Dijk R.E."xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/author | "Oguro-Ando A."xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/author | "Zuko A."xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/author | "Taggenbrock R.L."xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/name | "Front Mol Neurosci"xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/pages | "143"xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/title | "Association of Cell Adhesion Molecules Contactin-6 and Latrophilin-1 Regulates Neuronal Apoptosis."xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/28018171 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28018171 |
| http://purl.uniprot.org/citations/28018171 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28018171 |
| http://purl.uniprot.org/uniprot/#_E9Q9Q9-mappedCitation-28018171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28018171 |
| http://purl.uniprot.org/uniprot/#_E0CY26-mappedCitation-28018171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28018171 |
| http://purl.uniprot.org/uniprot/#_P70677-mappedCitation-28018171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28018171 |