| http://purl.uniprot.org/citations/28030805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28030805 | http://www.w3.org/2000/01/rdf-schema#comment | "Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a widely secreted protein that regulates cell motility, proliferation, and apoptosis. Although it is recognized that TIMP-1-tetraspanin CD63 regulates epithelial cell apoptosis and proliferation, how TIMP-1 controls cell motility is not well understood. In this study, we identify tetraspanin CD82 (also called KAI1) as a component of the promiscuous TIMP-1 interacting protein complex on cell surface of human pancreatic adenocarcinoma cells. CD82 directly binds to TIMP-1 N-terminal region through its large extracellular loop and co-localizes with TIMP-1 in both cancer cell lines and clinical samples. Moreover, CD82 facilitates membrane-bound TIMP-1 endocytosis, which significantly contributes to the anti-migration effect of TIMP-1. CD82 silencing partially eliminates these functions. TIMP-1 and CD82 expression status in patients with pancreatic ductal adenocarcinoma (PDAC) might demonstrate future usefulness as a differentiation marker and give us new insight into tumorigenic metastatic potential."xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.14133"xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/author | "Han X."xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/author | "Wu T."xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/author | "Yang N."xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/author | "Zhan S."xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/author | "Zhang X.A."xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/author | "Qiao N."xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/author | "Bleich D."xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/pages | "6496-6512"xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/title | "TIMP-1 and CD82, a promising combined evaluation marker for PDAC."xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/28030805 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28030805 |
| http://purl.uniprot.org/citations/28030805 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28030805 |
| http://purl.uniprot.org/uniprot/#_B3KQF4-mappedCitation-28030805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28030805 |
| http://purl.uniprot.org/uniprot/#_B4DJK3-mappedCitation-28030805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28030805 |
| http://purl.uniprot.org/uniprot/#_P01033-mappedCitation-28030805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28030805 |
| http://purl.uniprot.org/uniprot/#_Q6FGX5-mappedCitation-28030805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28030805 |