| http://purl.uniprot.org/citations/28032275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28032275 | http://www.w3.org/2000/01/rdf-schema#comment | "CD109 is a glycosylphosphatidylinositol-anchored glycoprotein that negatively regulates TGF-β signaling. CD109 was originally identified in hematopoietic tumors; however, the significance of CD109 in hematopoietic malignancies remains unclear. Here, we study the association of CD109 with diffuse large B-cell lymphoma (DLBCL) prognosis. Eighty-four DLBCL specimens were immunohistochemically analyzed for CD109 expression, and 31 and 53 cases were classified into low- and high-CD109 expression groups, respectively. CD109 expression was not associated with overall survival using the Kaplan-Meier analysis and log-rank tests (P = 0.17); however, a significant association was observed between high-CD109 expression and low-1-year survival (P = 0.01). Moreover, in combination with the revised International Prognostic Index (R-IPI), R-IPI-poor/CD109-high was associated with poorer prognosis compared with R-IPI-poor alone. We assessed TGF-β signaling in CD109-depleted Nalm6 cells (a human B-lymphoblastic leukemia/lymphoma cell line), and found prolonged Smad2 phosphorylation compared with control cells after TGF-β1 stimulation, suggesting that CD109 attenuates TGF-β1 signaling in human B-cell tumors. These results suggest that CD109 is a putative biomarker for identifying a high-risk group among DLBCL patients."xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12185-016-2173-1"xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/author | "Yokoyama M."xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/author | "Nakada N."xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/author | "Miyazaki K."xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/author | "Sakurai Y."xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/author | "Numata Y."xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/author | "Murakumo Y."xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/author | "Yanagisawa N."xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/author | "Higashihara M."xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/author | "Umezawa A."xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/author | "Jiang S.X."xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/author | "Ichinoe M."xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/author | "Okina S."xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/name | "Int J Hematol"xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/pages | "614-622"xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/title | "CD109, a negative regulator of TGF-beta signaling, is a putative risk marker in diffuse large B-cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/28032275 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28032275 |
| http://purl.uniprot.org/citations/28032275 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28032275 |
| http://purl.uniprot.org/uniprot/#_F1C639-mappedCitation-28032275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28032275 |
| http://purl.uniprot.org/uniprot/#_Q5XUM6-mappedCitation-28032275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28032275 |
| http://purl.uniprot.org/uniprot/#_Q5XUN1-mappedCitation-28032275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28032275 |