| http://purl.uniprot.org/citations/28039033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28039033 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon regulatory factor-1 (IRF-1) is a member of the interferon regulatory factor family. It acts as a transcriptional activator and plays a critical role in antiviral defense, immune response, cell growth regulation, apoptosis and cell differentiation. Deletions, mutations or aberrant splicing of IRF-1 would result in its functional inactivation, and closely related to the tumorigenesis. In this work, we identified an IRF-1 splicing transcript (IRF-1-s) in all-trans retinoic acid (ATRA)-treated acute promyelocytic leukemia (APL) cell line NB4 cells. It lost the exon 8 and 9 of the full length IRF-1, expressed in numerous cell types and could be induced to expression by ATRA in NB4 cells. It turned out similar biological activity as full length IRF-1 to enhance the transcription of interferon stimulated response element (ISRE)-containing target genes. Identification of IRF-1-s in NB4 cells would be benefit for our further exploring the signaling pathway of ATRA and interferons, as well as the mechanisms of differentiation of APL cells."xsd:string |
| http://purl.uniprot.org/citations/28039033 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2016.12.029"xsd:string |
| http://purl.uniprot.org/citations/28039033 | http://purl.uniprot.org/core/author | "Jin J."xsd:string |
| http://purl.uniprot.org/citations/28039033 | http://purl.uniprot.org/core/author | "Lou Y."xsd:string |
| http://purl.uniprot.org/citations/28039033 | http://purl.uniprot.org/core/author | "Xia D."xsd:string |
| http://purl.uniprot.org/citations/28039033 | http://purl.uniprot.org/core/author | "Yu M."xsd:string |
| http://purl.uniprot.org/citations/28039033 | http://purl.uniprot.org/core/author | "Tong J."xsd:string |
| http://purl.uniprot.org/citations/28039033 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28039033 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/28039033 | http://purl.uniprot.org/core/pages | "108-113"xsd:string |
| http://purl.uniprot.org/citations/28039033 | http://purl.uniprot.org/core/title | "Identification of an IRF-1 splicing transcript in APL cells sharing similar transactivation activity of the full length one."xsd:string |
| http://purl.uniprot.org/citations/28039033 | http://purl.uniprot.org/core/volume | "605"xsd:string |
| http://purl.uniprot.org/citations/28039033 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28039033 |
| http://purl.uniprot.org/citations/28039033 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28039033 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XK53-mappedCitation-28039033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28039033 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XK11-mappedCitation-28039033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28039033 |
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| http://purl.uniprot.org/uniprot/#_B4DQF0-mappedCitation-28039033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28039033 |
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| http://purl.uniprot.org/uniprot/#_Q59F37-mappedCitation-28039033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28039033 |
| http://purl.uniprot.org/uniprot/#_Q75MZ8-mappedCitation-28039033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28039033 |
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| http://purl.uniprot.org/uniprot/#_Q6FHN8-mappedCitation-28039033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28039033 |