| http://purl.uniprot.org/citations/28039326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28039326 | http://www.w3.org/2000/01/rdf-schema#comment | "AID deaminates C to U in either strand of Ig genes, exclusively producing C:G/G:C to T:A/A:T transition mutations if U is left unrepaired. Error-prone processing by UNG2 or mismatch repair diversifies mutation, predominantly at C:G or A:T base pairs, respectively. Here, we show that transversions at C:G base pairs occur by two distinct processing pathways that are dictated by sequence context. Within and near AGCT mutation hotspots, transversion mutation at C:G was driven by UNG2 without requirement for mismatch repair. Deaminations in AGCT were refractive both to processing by UNG2 and to high-fidelity base excision repair (BER) downstream of UNG2, regardless of mismatch repair activity. We propose that AGCT sequences resist faithful BER because they bind BER-inhibitory protein(s) and/or because hemi-deaminated AGCT motifs innately form a BER-resistant DNA structure. Distal to AGCT sequences, transversions at G were largely co-dependent on UNG2 and mismatch repair. We propose that AGCT-distal transversions are produced when apyrimidinic sites are exposed in mismatch excision patches, because completion of mismatch repair would require bypass of these sites."xsd:string |
| http://purl.uniprot.org/citations/28039326 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkw1300"xsd:string |
| http://purl.uniprot.org/citations/28039326 | http://purl.uniprot.org/core/author | "Weninger W."xsd:string |
| http://purl.uniprot.org/citations/28039326 | http://purl.uniprot.org/core/author | "Bosnjak D."xsd:string |
| http://purl.uniprot.org/citations/28039326 | http://purl.uniprot.org/core/author | "Durack T."xsd:string |
| http://purl.uniprot.org/citations/28039326 | http://purl.uniprot.org/core/author | "Jolly C.J."xsd:string |
| http://purl.uniprot.org/citations/28039326 | http://purl.uniprot.org/core/author | "Stevanovski I."xsd:string |
| http://purl.uniprot.org/citations/28039326 | http://purl.uniprot.org/core/author | "Thientosapol E.S."xsd:string |
| http://purl.uniprot.org/citations/28039326 | http://purl.uniprot.org/core/author | "Sharbeen G."xsd:string |
| http://purl.uniprot.org/citations/28039326 | http://purl.uniprot.org/core/author | "Lau K.K.E."xsd:string |
| http://purl.uniprot.org/citations/28039326 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28039326 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/28039326 | http://purl.uniprot.org/core/pages | "3146-3157"xsd:string |
| http://purl.uniprot.org/citations/28039326 | http://purl.uniprot.org/core/title | "Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2."xsd:string |
| http://purl.uniprot.org/citations/28039326 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/28039326 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28039326 |
| http://purl.uniprot.org/citations/28039326 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28039326 |
| http://purl.uniprot.org/uniprot/#_G3UWZ8-mappedCitation-28039326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28039326 |
| http://purl.uniprot.org/uniprot/#_G3UXD8-mappedCitation-28039326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28039326 |
| http://purl.uniprot.org/uniprot/#_P15919-mappedCitation-28039326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28039326 |
| http://purl.uniprot.org/uniprot/#_Q3TZI5-mappedCitation-28039326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28039326 |
| http://purl.uniprot.org/uniprot/#_P43247-mappedCitation-28039326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28039326 |
| http://purl.uniprot.org/uniprot/#_Q3TR87-mappedCitation-28039326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28039326 |
| http://purl.uniprot.org/uniprot/#_Q8C2F3-mappedCitation-28039326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28039326 |