http://purl.uniprot.org/citations/28042001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/28042001 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundSeveral host factors contribute to human immunodeficiency virus (HIV) disease progression in the absence of combination antiretroviral therapy (cART). Among them, the CC-chemokine receptor 5 (CCR5) is known to be the main co-receptor used by HIV-1 to enter target cells during the early stages of an HIV-1 infection.ObjectiveWe evaluated the association of CCR5(WT/Δ32) heterozygosity with HIV-1 reservoir size, lymphocyte differentiation, activation and immunosenescence in adolescents and young adults with perinatally acquired HIV infection receiving cART.MethodsCCR5 genotype was analysed in 242 patients with vertically transmitted HIV-1 infection from Paediatric Spanish AIDS Research Network Cohort (coRISpe). Proviral HIV-1 DNA was quantified by digital-droplet PCR, and T-cell phenotype was evaluated by flow cytometry in a subset of 24 patients (ten with CCR5(Δ32/WT) genotype and 14 with CCR5(WT/WT) genotype).ResultsTwenty-three patients were heterozygous for the Δ32 genotype but none was homozygous for the mutated CCR5 allele. We observed no difference in the HIV-1 reservoir size (455 and 578 copies of HIV-1 DNA per million CD4+ T cells in individuals with CCR5(WT/WT) and CCR5(Δ32/WT) genotypes, respectively; p 0.75) or in the immune activation markers between both genotype groups. However, we found that total HIV-1 DNA in CD4+ T cells correlated with the percentage of memory CD4+ T cells: a direct correlation in CCR5(WT/Δ32) patients but an inverse correlation in those with the CCR5(WT/WT) genotype.ConclusionsThis finding suggests a differential distribution of the viral reservoir compartment in CCR5(WT/Δ32) patients with perinatal HIV infection, which is a characteristic that may affect the design of strategies for reservoir elimination."xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmi.2016.12.020"xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/author | "Navarro M."xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/author | "Martinez-Bonet M."xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/author | "Ruiz-Mateos E."xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/author | "Munoz-Fernandez M.A."xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/author | "Diaz L."xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/author | "Martinez-Picado J."xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/author | "Leal M."xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/author | "Puertas M.C."xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/author | "Clemente M.I."xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/author | "Gonzalez-Serna A."xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/author | "Moron-Lopez S."xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/name | "Clin Microbiol Infect"xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/pages | "318-324"xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/title | "Relationship between CCR5pisup>(WT/Delta32)pi/sup> heterozygosity and HIV-1 reservoir size in adolescents and young adults with perinatally acquired HIV-1 infection."xsd:string |
http://purl.uniprot.org/citations/28042001 | http://purl.uniprot.org/core/volume | "23"xsd:string |
http://purl.uniprot.org/citations/28042001 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28042001 |
http://purl.uniprot.org/citations/28042001 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28042001 |
http://purl.uniprot.org/uniprot/#_A0A089G6S6-mappedCitation-28042001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28042001 |
http://purl.uniprot.org/uniprot/#_A0A089G6S9-mappedCitation-28042001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28042001 |
http://purl.uniprot.org/uniprot/#_A0A089G7F7-mappedCitation-28042001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28042001 |
http://purl.uniprot.org/uniprot/#_A0A089G7G0-mappedCitation-28042001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28042001 |