| http://purl.uniprot.org/citations/28053050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28053050 | http://www.w3.org/2000/01/rdf-schema#comment | "To understand the cause of Parkinson's disease (PD), it is important to determine the functional interactions between factors linked to the disease. Parkin is associated with autosomal recessive early-onset PD, and controls the transcription of PGC-1α, a master regulator of mitochondrial biogenesis. These two factors functionally interact to regulate the turnover and quality of mitochondria, by increasing both mitophagic activity and mitochondria biogenesis. In cortical neurons, co-expressing PGC-1α and Parkin increases the number of mitochondria, enhances maximal respiration, and accelerates the recovery of the mitochondrial membrane potential following mitochondrial uncoupling. PGC-1α enhances Mfn2 transcription, but also leads to increased degradation of the Mfn2 protein, a key ubiquitylation target of Parkin on mitochondria. In vivo, Parkin has significant protective effects on the survival and function of nigral dopaminergic neurons in which the chronic expression of PGC-1α is induced. Ultrastructural analysis shows that these two factors together control the density of mitochondria and their interaction with the endoplasmic reticulum. These results highlight the combined effects of Parkin and PGC-1α in the maintenance of mitochondrial homeostasis in dopaminergic neurons. These two factors synergistically control the quality and function of mitochondria, which is important for the survival of neurons in Parkinson's disease."xsd:string |
| http://purl.uniprot.org/citations/28053050 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddw418"xsd:string |
| http://purl.uniprot.org/citations/28053050 | http://purl.uniprot.org/core/author | "Schneider B.L."xsd:string |
| http://purl.uniprot.org/citations/28053050 | http://purl.uniprot.org/core/author | "Zheng L."xsd:string |
| http://purl.uniprot.org/citations/28053050 | http://purl.uniprot.org/core/author | "Moore D.J."xsd:string |
| http://purl.uniprot.org/citations/28053050 | http://purl.uniprot.org/core/author | "Auwerx J."xsd:string |
| http://purl.uniprot.org/citations/28053050 | http://purl.uniprot.org/core/author | "D'Amico D."xsd:string |
| http://purl.uniprot.org/citations/28053050 | http://purl.uniprot.org/core/author | "Moullan N."xsd:string |
| http://purl.uniprot.org/citations/28053050 | http://purl.uniprot.org/core/author | "Bernard-Marissal N."xsd:string |
| http://purl.uniprot.org/citations/28053050 | http://purl.uniprot.org/core/author | "Aebischer P."xsd:string |
| http://purl.uniprot.org/citations/28053050 | http://purl.uniprot.org/core/author | "Knott G."xsd:string |
| http://purl.uniprot.org/citations/28053050 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28053050 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/28053050 | http://purl.uniprot.org/core/pages | "582-598"xsd:string |
| http://purl.uniprot.org/citations/28053050 | http://purl.uniprot.org/core/title | "Parkin functionally interacts with PGC-1alpha to preserve mitochondria and protect dopaminergic neurons."xsd:string |
| http://purl.uniprot.org/citations/28053050 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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