| http://purl.uniprot.org/citations/28055980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28055980 | http://www.w3.org/2000/01/rdf-schema#comment | "The limited number of available treatments for patients with small-cell lung cancer (SCLC) has prompted us to further investigate the biology of SCLC by molecular profiling. We collected formalin-fixed paraffin-embedded tumor samples from 127 patients with SCLC, who had undergone surgery at 16 institutions between January 2003 and January 2013, and analyzed the association between disease-specific survival and protein expression of c-kit, c-Met, epidermal growth factor receptor, human EGFR-related 2, vascular endothelial growth factor receptor II, anaplastic lymphoma kinase, mediator complex subunit 12 (MED12), and transforming growth factor beta receptor II (TGF-βRII) by immunohistochemistry (IHC). Of the 125 evaluable samples, all tumors expressed MED12, and 123 samples (98.4%) expressed TGF-βRII. MED12 was highly expressed in the nucleus in 92% of the positive samples while TGF-βRII was highly expressed in the cytoplasm in 55% of the positive samples. High c-kit expression was an independent favorable prognostic marker confirmed by multivariate analysis (hazard ratio: 0.543, 95% confidence interval: 0.310-0.953, p = 0.033). Both the relapse free-survival and overall survival of patients who underwent adjuvant chemotherapy were statistically longer in those with high c-kit expression (n = 38) than those with intermediate, low, or no c-kit expression (n = 19) (not reached vs 11.6 months, p = 0.021; not reached vs 25.9 months, p = 0.028). IHC for c-kit may offer a prognostic marker for early-stage SCLC, and the results for MED12 and TGF-βRII may suggest the biological characteristics of SCLC. Further investigation of the roles of their related molecules in early stage SCLC is required."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.14410"xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Nishihara H."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Fujita Y."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Harada M."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Kikuchi H."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Ishida T."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Harada T."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Minami Y."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Nishimura M."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Yamazaki S."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Watanabe N."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Higuchi M."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Goto A."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Kojima T."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Dosaka-Akita H."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Yokouchi H."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Tanaka F."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Munakata M."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Takamura K."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Oizumi S."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Uramoto H."xsd:string |
| http://purl.uniprot.org/citations/28055980 | http://purl.uniprot.org/core/author | "Isobe H."xsd:string |