| http://purl.uniprot.org/citations/28057438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28057438 | http://www.w3.org/2000/01/rdf-schema#comment | "Fluid-phase endocytosis is a homeostatic process with an unknown role in tumor initiation. The driver mutation in pancreatic ductal adenocarcinoma (PDAC) is constitutively active KRasG12D, which induces neoplastic transformation of acinar cells through acinar-to-ductal metaplasia (ADM). We have previously shown that KRasG12D-induced ADM is dependent on RAC1 and EGF receptor (EGFR) by a not fully clarified mechanism. Using three-dimensional mouse and human acinar tissue cultures and genetically engineered mouse models, we provide evidence that (i) KRasG12D leads to EGFR-dependent sustained fluid-phase endocytosis (FPE) during acinar metaplasia; (ii) variations in plasma membrane tension increase FPE and lead to ADM in vitro independently of EGFR; and (iii) that RAC1 regulates ADM formation partially through actin-dependent regulation of FPE. In addition, mice with a pancreas-specific deletion of the Neural-Wiskott-Aldrich syndrome protein (N-WASP), a regulator of F-actin, have reduced FPE and impaired ADM emphasizing the in vivo relevance of our findings. This work defines a new role of FPE as a tumor initiating mechanism."xsd:string |
| http://purl.uniprot.org/citations/28057438 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ebiom.2016.12.013"xsd:string |
| http://purl.uniprot.org/citations/28057438 | http://purl.uniprot.org/core/author | "Lubeseder-Martellato C."xsd:string |
| http://purl.uniprot.org/citations/28057438 | http://purl.uniprot.org/core/author | "Hidalgo-Sastre A."xsd:string |
| http://purl.uniprot.org/citations/28057438 | http://purl.uniprot.org/core/author | "Schmid R.M."xsd:string |
| http://purl.uniprot.org/citations/28057438 | http://purl.uniprot.org/core/author | "Heid I."xsd:string |
| http://purl.uniprot.org/citations/28057438 | http://purl.uniprot.org/core/author | "Siveke J.T."xsd:string |
| http://purl.uniprot.org/citations/28057438 | http://purl.uniprot.org/core/author | "Briel T."xsd:string |
| http://purl.uniprot.org/citations/28057438 | http://purl.uniprot.org/core/author | "Alexandrow K."xsd:string |
| http://purl.uniprot.org/citations/28057438 | http://purl.uniprot.org/core/author | "Boos S.L."xsd:string |
| http://purl.uniprot.org/citations/28057438 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28057438 | http://purl.uniprot.org/core/name | "EBioMedicine"xsd:string |
| http://purl.uniprot.org/citations/28057438 | http://purl.uniprot.org/core/pages | "90-99"xsd:string |
| http://purl.uniprot.org/citations/28057438 | http://purl.uniprot.org/core/title | "Oncogenic KRas-induced Increase in Fluid-phase Endocytosis is Dependent on N-WASP and is Required for the Formation of Pancreatic Preneoplastic Lesions."xsd:string |
| http://purl.uniprot.org/citations/28057438 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/28057438 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28057438 |
| http://purl.uniprot.org/citations/28057438 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28057438 |
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| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-28057438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28057438 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-28057438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28057438 |
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