| http://purl.uniprot.org/citations/28057752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28057752 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms underlying the effects of exocrine dysfunction on the development of diabetes remain largely unknown. Here we show that pancreatic depletion of SMAD7 resulted in age-dependent increases in β cell dysfunction with accelerated glucose intolerance, followed by overt diabetes. The accelerated β cell dysfunction and loss of proliferation capacity, two features of β cell aging, appeared to be non-cell-autonomous, secondary to the adjacent exocrine failure as a "bystander effect." Increased Forkhead box protein 1 (FoxO1) acetylation and nuclear retention was followed by progressive FoxO1 loss in β cells that marked the onset of diabetes. Moreover, forced FoxO1 expression in β cells prevented β cell dysfunction and loss in this model. Thus, we present a model of accelerated β cell aging that may be useful for studying the mechanisms underlying β cell failure in diabetes. Moreover, we provide evidence highlighting a critical role of FoxO1 in maintaining β cell identity in the context of SMAD7 failure."xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m116.770032"xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/author | "Dong H."xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/author | "Xiao X."xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/author | "Guo P."xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/author | "Shiota C."xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/author | "Prasadan K."xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/author | "Gittes G.K."xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/author | "Fischbach S."xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/author | "Fusco J."xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/pages | "3456-3465"xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/title | "Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated beta Cell Aging in Pancreas-specific SMAD7 Mutant Mice."xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://purl.uniprot.org/core/volume | "292"xsd:string |
| http://purl.uniprot.org/citations/28057752 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28057752 |
| http://purl.uniprot.org/citations/28057752 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28057752 |
| http://purl.uniprot.org/uniprot/#_B2RPW6-mappedCitation-28057752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28057752 |
| http://purl.uniprot.org/uniprot/#_A2ATA7-mappedCitation-28057752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28057752 |
| http://purl.uniprot.org/uniprot/#_O35253-mappedCitation-28057752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28057752 |
| http://purl.uniprot.org/uniprot/#_G3UX42-mappedCitation-28057752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28057752 |
| http://purl.uniprot.org/uniprot/#_G3UXH8-mappedCitation-28057752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28057752 |