| http://purl.uniprot.org/citations/28059703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28059703 | http://www.w3.org/2000/01/rdf-schema#comment | "Rapidly proliferating cells switch from oxidative phosphorylation to aerobic glycolysis plus glutaminolysis, markedly increasing glucose and glutamine catabolism. Although Otto Warburg first described aerobic glycolysis in cancer cells >90 years ago, the primary purpose of this metabolic switch remains controversial. The hexosamine biosynthetic pathway requires glucose and glutamine for de novo synthesis of UDP-GlcNAc, a sugar-nucleotide that inhibits receptor endocytosis and signaling by promoting N-acetylglucosamine branching of Asn (N)-linked glycans. Here, we report that aerobic glycolysis and glutaminolysis co-operatively reduce UDP-GlcNAc biosynthesis and N-glycan branching in mouse T cell blasts by starving the hexosamine pathway of glucose and glutamine. This drives growth and pro-inflammatory TH17 over anti-inflammatory-induced T regulatory (iTreg) differentiation, the latter by promoting endocytic loss of IL-2 receptor-α (CD25). Thus, a primary function of aerobic glycolysis and glutaminolysis is to co-operatively limit metabolite supply to N-glycan biosynthesis, an activity with widespread implications for autoimmunity and cancer."xsd:string |
| http://purl.uniprot.org/citations/28059703 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.21330"xsd:string |
| http://purl.uniprot.org/citations/28059703 | http://purl.uniprot.org/core/author | "Demetriou M."xsd:string |
| http://purl.uniprot.org/citations/28059703 | http://purl.uniprot.org/core/author | "Araujo L."xsd:string |
| http://purl.uniprot.org/citations/28059703 | http://purl.uniprot.org/core/author | "Mkhikian H."xsd:string |
| http://purl.uniprot.org/citations/28059703 | http://purl.uniprot.org/core/author | "Mortales C.L."xsd:string |
| http://purl.uniprot.org/citations/28059703 | http://purl.uniprot.org/core/author | "Khim P."xsd:string |
| http://purl.uniprot.org/citations/28059703 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28059703 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28059703 | http://purl.uniprot.org/core/pages | "e21330"xsd:string |
| http://purl.uniprot.org/citations/28059703 | http://purl.uniprot.org/core/title | "Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation."xsd:string |
| http://purl.uniprot.org/citations/28059703 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/28059703 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28059703 |
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| http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-28059703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28059703 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC46-mappedCitation-28059703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28059703 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EI60-mappedCitation-28059703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28059703 |
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| http://purl.uniprot.org/uniprot/#_Q62386-mappedCitation-28059703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28059703 |
| http://purl.uniprot.org/uniprot/#_J3JS24-mappedCitation-28059703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28059703 |
| http://purl.uniprot.org/uniprot/#_Q99JB6-mappedCitation-28059703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28059703 |
| http://purl.uniprot.org/uniprot/#_V5LWQ0-mappedCitation-28059703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28059703 |
| http://purl.uniprot.org/uniprot/#_Q059T5-mappedCitation-28059703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28059703 |
| http://purl.uniprot.org/uniprot/#_P27808-mappedCitation-28059703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28059703 |