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http://purl.uniprot.org/citations/28062493http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28062493http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28062493http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The objective of this study is to investigate the role and underlying mechanism of Olfactomedin 2 (Olfm2) in smooth muscle cell (SMC) phenotypic modulation and vascular remodeling.

Approach and results

Platelet-derived growth factor-BB induces Olfm2 expression in primary SMCs while modulating SMC phenotype as shown by the downregulation of SMC marker proteins. Knockdown of Olfm2 blocks platelet-derived growth factor-BB-induced SMC phenotypic modulation, proliferation, and migration. Conversely, Olfm2 overexpression inhibits SMC marker expression. Mechanistically, Olfm2 promotes the interaction of serum response factor with the runt-related transcription factor 2 that is induced by platelet-derived growth factor-BB, leading to a decreased interaction between serum response factor and myocardin, causing a repression of SMC marker gene transcription and consequently SMC phenotypic modulation. Animal studies show that Olfm2 is upregulated in balloon-injured rat carotid arteries. Knockdown of Olfm2 effectively inhibits balloon injury-induced neointima formation. Importantly, knockout of Olfm2 in mice profoundly suppresses wire injury-induced neointimal hyperplasia while restoring SMC contractile protein expression, suggesting that Olfm2 plays a critical role in SMC phenotypic modulation in vivo.

Conclusions

Olfm2 is a novel factor mediating SMC phenotypic modulation. Thus, Olfm2 may be a potential target for treating injury-induced proliferative vascular diseases."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.org/dc/terms/identifier"doi:10.1161/atvbaha.116.308606"xsd:string
http://purl.uniprot.org/citations/28062493http://purl.org/dc/terms/identifier"doi:10.1161/atvbaha.116.308606"xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/author"Tomarev S.I."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/author"Tomarev S.I."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/author"Chen S.Y."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/author"Chen S.Y."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/author"Shi N."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/author"Shi N."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/author"Li C.X."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/author"Li C.X."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/author"Cui X.B."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/author"Cui X.B."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/name"Arterioscler. Thromb. Vasc. Biol."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/name"Arterioscler. Thromb. Vasc. Biol."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/pages"446-454"xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/pages"446-454"xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/title"Olfactomedin 2 regulates smooth muscle phenotypic modulation and vascular remodeling through mediating Runt-related transcription factor 2 binding to serum response factor."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/title"Olfactomedin 2 regulates smooth muscle phenotypic modulation and vascular remodeling through mediating Runt-related transcription factor 2 binding to serum response factor."xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/volume"37"xsd:string
http://purl.uniprot.org/citations/28062493http://purl.uniprot.org/core/volume"37"xsd:string
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