| http://purl.uniprot.org/citations/28074340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28074340 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysregulated expression of lysosomal cysteine cathepsins is associated with adverse cardiac remodeling, a characteristic of several cardiovascular diseases. However, the information regarding the role of cysteine cathepsin L (CTSL) and cathepsin B (CTSB) in dilated cardiomyopathy (DCM) is limited. The present study was aimed to investigate the expression of CTSL and CTSB in animal model of doxorubicin (doxo)-induced cardiomyopathy as well as in peripheral blood samples of DCM patients. Cardiac tissue sections from doxo-treated and control rats were used to study the expression of CTSL and CTSB by enzyme assay and immunohistochemistry (IHC). Peripheral blood mononuclear cells (PBMCs) isolated from DCM patients (n = 29) along with age-matched healthy controls (n = 28) were used to assay enzymatic activity of these cathepsins. Activities of these proteases were further correlated with echocardiographic parameters of DCM patients. A significant increase in CTSL activity and protein expression was observed with no changes in CTSB levels in doxo-treated rats as compared to controls. We also observed a drastic increase in the functional activity of cathepsin L+cathepsin B (CTSL+B), CTSL, and CTSB in DCM patients compared to controls (p ≤ 0.001). Increased levels of these proteases exhibited a statistically significant correlation with reduced left ventricular ejection fraction (LVEF) in DCM patients (ρ = -0.58, p = 0.01). For the first time, this study demonstrates a correlation between increased expression of CTSL and CTSB in PBMCs with severity of left ventricular dysfunction in DCM patients. Thus, these proteases may serve as blood-based biomarker of DCM and prove useful in its management."xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-016-2924-6"xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/author | "Kumar M."xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/author | "Singh R."xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/author | "Mehra S."xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/author | "Narang R."xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/author | "Thakur B."xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/author | "Chauhan S.S."xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/author | "Rani N."xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/author | "Manchanda M."xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/author | "Arya D.S."xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/author | "Arava S."xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/name | "Mol Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/pages | "139-147"xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/title | "Clinical significance of cathepsin L and cathepsin B in dilated cardiomyopathy."xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://purl.uniprot.org/core/volume | "428"xsd:string |
| http://purl.uniprot.org/citations/28074340 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28074340 |
| http://purl.uniprot.org/citations/28074340 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28074340 |
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| http://purl.uniprot.org/uniprot/#_A8K2H4-mappedCitation-28074340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28074340 |
| http://purl.uniprot.org/uniprot/#_A5PLM9-mappedCitation-28074340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28074340 |
| http://purl.uniprot.org/uniprot/#_B3KUJ8-mappedCitation-28074340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28074340 |
| http://purl.uniprot.org/uniprot/#_B3KQK4-mappedCitation-28074340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28074340 |